Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue

Ichiro Hayakawa; Shuya Shioda; Akiyuki Ikedo; Hideo Kigoshi

doi:10.1246/bcsj.20130342

Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue

Ichiro Hayakawa, Shuya Shioda, Akiyuki Ikedo, Hideo Kigoshi

Faculty of Engineering

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.

Original language	English
Pages (from-to)	544-549
Number of pages	6
Journal	Bulletin of the Chemical Society of Japan
Volume	87
Issue number	4
DOIs	https://doi.org/10.1246/bcsj.20130342
Publication status	Published - 2014

ASJC Scopus subject areas

Chemistry(all)

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abstract = "Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.",

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AU - Ikedo, Akiyuki

AU - Kigoshi, Hideo

PY - 2014

Y1 - 2014

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AB - Glaziovianin A and its O7-propargyl analogue are potent cytotoxic isoflavones. We found that the O7-propargyl analogue completely arrested cell-cycle progression. We have achieved the large-scale synthesis of glaziovianin A and its O7-propargyl analogue for further in vivo experimentation.

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ER -

Practical synthesis of glaziovianin A, a cytotoxic isoflavone, and its O7-propargyl analogue

Abstract

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