Preparation and characterization of low-crystallized hydroxyapatitenanoporous plates and granules

Mayo Uehira, Masahiro Okada, Shoji Takeda, Naoyuki Matsumoto

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


We examined the conditions for preparing nanoporous hydroxyapatite (HAp) plates and granules by assembling low-crystallinity HAp nanoparticles without template/binder molecules or high-temperature/pressure treatments. We first prepared HAp nanoparticles with different particle sizes and then the nanoporous plate or granule was prepared by drying an aqueous dispersion of HAp nanopar-ticles on an oil substrate. The hydrophobic oil substrate was preferable to prevent crack formation inHAp plates. The size of the HAp plate could be controlled by the concentration of HAp dispersion, andmillimeter-sized granules were obtained by drying a small volume of HAp dispersion on/in the oil sub-strate. The nanoparticle-assembled HAp had nanosized pores, and the pore size could be changed by adjusting the size of the HAp nanoparticles used. It was found that both hydrophilic and hydrophobicliquids could infiltrate inside the nanopores. The nanoporous HAp granules also could adsorb and releaseproteins, and the protein adsorption and release delayed in the presence of the nanopores.

Original languageEnglish
Pages (from-to)195-202
Number of pages8
JournalApplied Surface Science
Publication statusPublished - 2013
Externally publishedYes


  • Assembly
  • Hydroxyapatite
  • Nanoparticle
  • Nanopore
  • Proteinadsorption
  • Transparency

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics
  • General Physics and Astronomy
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films


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