Preparation of poly(succinimide) microcapsules with pH-response of drug release

Satoru Nishino; Tsutomu Ono; Yoshiro Kitamura; Akio Kishida; Hidekazu Yoshizawa

Preparation of poly(succinimide) microcapsules with pH-response of drug release

Satoru Nishino, Tsutomu Ono, Yoshiro Kitamura, Akio Kishida, Hidekazu Yoshizawa

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We prepared the poly(succinimide) (hereafter abbreviated as PSI) microcapsules with antitumor agent showing a pH-responsive release. PSI microcapsules enclosing Irinotecan hydrochloride (CPT-11) were prepared by solvent evaporation method via O/O emulsion system. The obtained PSI microcapsules had a smooth surface and were spherical with diameter of approximately 30 urn. CPT-11 was successfully microencapsulated with high entrapment efficiency of above 90 %. From the results of in vitro release test in an aqueous media with variety of pH, CPT-11 was constantly released for 1 week with no initial burst at pH 5. On the other hand, it was clearly observed the pH-dependency of release rate. That is, the release rate was increased at the higher pH in aqueous media. From SEM observations of internal structure of PSI microcapsules after incubation in aqueous media, it was found that the hole was observed in center of microcapsules.

Original language	English
Title of host publication	2006 AIChE Annual Meeting
Publication status	Published - Dec 1 2006
Event	2006 AIChE Annual Meeting - San Francisco, CA, United States Duration: Nov 12 2006 → Nov 17 2006

Publication series

Name	AIChE Annual Meeting, Conference Proceedings

Other

Other	2006 AIChE Annual Meeting
Country/Territory	United States
City	San Francisco, CA
Period	11/12/06 → 11/17/06

ASJC Scopus subject areas

Chemical Engineering(all)
Chemistry(all)

Cite this

@inproceedings{23fb21c360c34a01b8f831052c70cb78,

title = "Preparation of poly(succinimide) microcapsules with pH-response of drug release",

abstract = "We prepared the poly(succinimide) (hereafter abbreviated as PSI) microcapsules with antitumor agent showing a pH-responsive release. PSI microcapsules enclosing Irinotecan hydrochloride (CPT-11) were prepared by solvent evaporation method via O/O emulsion system. The obtained PSI microcapsules had a smooth surface and were spherical with diameter of approximately 30 urn. CPT-11 was successfully microencapsulated with high entrapment efficiency of above 90 %. From the results of in vitro release test in an aqueous media with variety of pH, CPT-11 was constantly released for 1 week with no initial burst at pH 5. On the other hand, it was clearly observed the pH-dependency of release rate. That is, the release rate was increased at the higher pH in aqueous media. From SEM observations of internal structure of PSI microcapsules after incubation in aqueous media, it was found that the hole was observed in center of microcapsules.",

author = "Satoru Nishino and Tsutomu Ono and Yoshiro Kitamura and Akio Kishida and Hidekazu Yoshizawa",

year = "2006",

month = dec,

day = "1",

language = "English",

isbn = "081691012X",

series = "AIChE Annual Meeting, Conference Proceedings",

booktitle = "2006 AIChE Annual Meeting",

note = "2006 AIChE Annual Meeting ; Conference date: 12-11-2006 Through 17-11-2006",

}

TY - GEN

T1 - Preparation of poly(succinimide) microcapsules with pH-response of drug release

AU - Nishino, Satoru

AU - Ono, Tsutomu

AU - Kitamura, Yoshiro

AU - Kishida, Akio

AU - Yoshizawa, Hidekazu

PY - 2006/12/1

Y1 - 2006/12/1

N2 - We prepared the poly(succinimide) (hereafter abbreviated as PSI) microcapsules with antitumor agent showing a pH-responsive release. PSI microcapsules enclosing Irinotecan hydrochloride (CPT-11) were prepared by solvent evaporation method via O/O emulsion system. The obtained PSI microcapsules had a smooth surface and were spherical with diameter of approximately 30 urn. CPT-11 was successfully microencapsulated with high entrapment efficiency of above 90 %. From the results of in vitro release test in an aqueous media with variety of pH, CPT-11 was constantly released for 1 week with no initial burst at pH 5. On the other hand, it was clearly observed the pH-dependency of release rate. That is, the release rate was increased at the higher pH in aqueous media. From SEM observations of internal structure of PSI microcapsules after incubation in aqueous media, it was found that the hole was observed in center of microcapsules.

AB - We prepared the poly(succinimide) (hereafter abbreviated as PSI) microcapsules with antitumor agent showing a pH-responsive release. PSI microcapsules enclosing Irinotecan hydrochloride (CPT-11) were prepared by solvent evaporation method via O/O emulsion system. The obtained PSI microcapsules had a smooth surface and were spherical with diameter of approximately 30 urn. CPT-11 was successfully microencapsulated with high entrapment efficiency of above 90 %. From the results of in vitro release test in an aqueous media with variety of pH, CPT-11 was constantly released for 1 week with no initial burst at pH 5. On the other hand, it was clearly observed the pH-dependency of release rate. That is, the release rate was increased at the higher pH in aqueous media. From SEM observations of internal structure of PSI microcapsules after incubation in aqueous media, it was found that the hole was observed in center of microcapsules.

UR - http://www.scopus.com/inward/record.url?scp=57049099117&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57049099117&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:57049099117

SN - 081691012X

SN - 9780816910120

T3 - AIChE Annual Meeting, Conference Proceedings

BT - 2006 AIChE Annual Meeting

T2 - 2006 AIChE Annual Meeting

Y2 - 12 November 2006 through 17 November 2006

ER -

Preparation of poly(succinimide) microcapsules with pH-response of drug release

Abstract

Publication series

Other

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this