Preparation of renieramycin left-half model compounds

Keiyo Nakai, Keiji Kubo, Masashi Yokoya, Naoki Saito

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Model compounds of the left-half of renieramycins, which are anticancer marine natural products having an α-aminonitrile functionality, were prepared from phenylalanine derivatives. The key step of the transformation is the stereospecific construction of 1,3-cis stereochemistry via an exomethylene intermediate. The stereoselective α-aminonitrile formation under kinetically controlled conditions is also discussed. The initial cytotoxicity profiles are presented.

Original languageEnglish
Pages (from-to)6529-6545
Number of pages17
Issue number37
Publication statusPublished - Sept 16 2014
Externally publishedYes


  • Cytotoxicity
  • Isoquinoline
  • Marine natural product
  • Preparation
  • Renieramycin

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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