Preparation of tiny biodegradable capsules using electrocapillary emulsification

Masahiko Abe, Ai Nakayama, Tamotsu Kondo, Hiroshi Morishita, Koji Tsuchiya, Shigenori Utsumi, Takahiro Ohkubo, Hideki Sakai

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of ∼10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.

Original languageEnglish
Pages (from-to)777-786
Number of pages10
JournalJournal of Microencapsulation
Issue number8
Publication statusPublished - Dec 2007
Externally publishedYes


  • Biodegradable capsule
  • Electrocapillary emulsification
  • Lactoferrin
  • Polycyanoacrylate
  • Polymerization

ASJC Scopus subject areas

  • Bioengineering
  • Pharmaceutical Science
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Colloid and Surface Chemistry


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