TY - JOUR
T1 - Presence of LuxS/AI-2 based quorum-sensing system in Vibrio mimicus
T2 - LuxO controls protease activity
AU - Sultan, Zafar
AU - Miyoshi, Shin Ichi
AU - Shinoda, Sumio
PY - 2006
Y1 - 2006
N2 - Presence of the quorum-sensing regulation system in Vibrio mimicus was investigated. The culture supernatants of V. mimicus strains were found to possess AI-2 autoinducer like activity, and the strains were found to harbor the genes which are homologous to luxS, luxO, and luxR of V. harveyi. These genes of V. harveyi have been shown to be important components of V. harveyi-like quorum-sensing system. The luxO gene homologue known to encode LuxO, the central component of the regulation system, was disrupted, and effects on protease and hemolysin activity were studied. Disruption of luxO gene resulted in the increased protease activity, but the hemolysin activity did not vary considerably.
AB - Presence of the quorum-sensing regulation system in Vibrio mimicus was investigated. The culture supernatants of V. mimicus strains were found to possess AI-2 autoinducer like activity, and the strains were found to harbor the genes which are homologous to luxS, luxO, and luxR of V. harveyi. These genes of V. harveyi have been shown to be important components of V. harveyi-like quorum-sensing system. The luxO gene homologue known to encode LuxO, the central component of the regulation system, was disrupted, and effects on protease and hemolysin activity were studied. Disruption of luxO gene resulted in the increased protease activity, but the hemolysin activity did not vary considerably.
KW - Autoinducer
KW - Quorum-sensing
KW - Vibrio mimicus
KW - Virulence
UR - http://www.scopus.com/inward/record.url?scp=33646836267&partnerID=8YFLogxK
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U2 - 10.1111/j.1348-0421.2006.tb03808.x
DO - 10.1111/j.1348-0421.2006.tb03808.x
M3 - Article
C2 - 16714849
AN - SCOPUS:33646836267
SN - 0385-5600
VL - 50
SP - 407
EP - 417
JO - MICROBIOLOGY and IMMUNOLOGY
JF - MICROBIOLOGY and IMMUNOLOGY
IS - 5
ER -