Presence of nitric oxide-sensing systems in the human pathogen vibrio vulnificus

Abdelaziz Elgaml, Shin Ichi Miyoshi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Vibrio vulnificus is a halophilic estuarine bacterium, but this species causes fatal septicemia in humans. V. vulnificus may encounter many kinds of stresses either in the natural environment or in the human body. One of the striking stresses is the exposure to the reactive oxygen species including nitric oxide (NO). The present study revealed that NO could participate in the regulation of the V. vulnificus community behavior. When the bacterium was cultivated in the presence of sub-lethal doses of an NO donor, the expression of the genes encoding NO-detoxifying enzymes was significantly increased. The NO donor was also found to cause significant increase in production of a metalloprotease, a putative virulence factor, by the bacterium.

Original languageEnglish
Pages (from-to)199-203
Number of pages5
JournalBiocontrol science
Issue number3
Publication statusPublished - 2015


  • Detoxification
  • Nitric oxide
  • Oxidative stress
  • Vibrio vulnificus

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health


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