Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010

Nozomu Wada; Tetsuya Yasunaka; Fusao Ikeda; Sohji Nishina; Masaaki Korenaga; Keisuke Hino; Shin Ichi Fujioka; Toshiya Osawa; Tatsuya Itoshima; Miwa Kawanaka; Gotaro Yamada; Kazuya Kariyama; Hiroki Takayama; Junichi Kubota; Yoichi Morimoto; Takaaki Mizushima; Haruhiko Yamashita; Hiroaki Tanioka; Yuji Negoro; Junichi Toshimori; Haruhiko Kobashi; Atsushi Hirano; Yasuo Itano; Akinobu Takaki; Kazuhide Yamamoto

Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010

Nozomu Wada, Tetsuya Yasunaka, Fusao Ikeda, Sohji Nishina, Masaaki Korenaga, Keisuke Hino, Shin Ichi Fujioka, Toshiya Osawa, Tatsuya Itoshima, Miwa Kawanaka, Gotaro Yamada, Kazuya Kariyama, Hiroki Takayama, Junichi Kubota, Yoichi Morimoto, Takaaki Mizushima, Haruhiko Yamashita, Hiroaki Tanioka, Yuji Negoro, Junichi ToshimoriHaruhiko Kobashi, Atsushi Hirano, Yasuo Itano, Akinobu Takaki, Kazuhide Yamamoto

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.

Original language	English
Pages (from-to)	243-247
Number of pages	5
Journal	Acta medica Okayama
Volume	68
Issue number	4
Publication status	Published - 2014

Keywords

Acute hepatitis
Hepatitis B virus

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Wada, N., Yasunaka, T., Ikeda, F., Nishina, S., Korenaga, M., Hino, K., Fujioka, S. I., Osawa, T., Itoshima, T., Kawanaka, M., Yamada, G., Kariyama, K., Takayama, H., Kubota, J., Morimoto, Y., Mizushima, T., Yamashita, H., Tanioka, H., Negoro, Y., ... Yamamoto, K. (2014). Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010. Acta medica Okayama, 68(4), 243-247.

Wada, N, Yasunaka, T, Ikeda, F, Nishina, S, Korenaga, M, Hino, K, Fujioka, SI, Osawa, T, Itoshima, T, Kawanaka, M, Yamada, G, Kariyama, K, Takayama, H, Kubota, J, Morimoto, Y, Mizushima, T, Yamashita, H, Tanioka, H, Negoro, Y, Toshimori, J, Kobashi, H, Hirano, A, Itano, Y, Takaki, A & Yamamoto, K 2014, 'Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010', Acta medica Okayama, vol. 68, no. 4, pp. 243-247.

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title = "Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010",

abstract = "Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.",

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T1 - Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010

AU - Wada, Nozomu

AU - Yasunaka, Tetsuya

AU - Ikeda, Fusao

AU - Nishina, Sohji

AU - Korenaga, Masaaki

AU - Hino, Keisuke

AU - Fujioka, Shin Ichi

AU - Osawa, Toshiya

AU - Itoshima, Tatsuya

AU - Kawanaka, Miwa

AU - Yamada, Gotaro

AU - Kariyama, Kazuya

AU - Takayama, Hiroki

AU - Kubota, Junichi

AU - Morimoto, Yoichi

AU - Mizushima, Takaaki

AU - Yamashita, Haruhiko

AU - Tanioka, Hiroaki

AU - Negoro, Yuji

AU - Toshimori, Junichi

AU - Kobashi, Haruhiko

AU - Hirano, Atsushi

AU - Itano, Yasuo

AU - Takaki, Akinobu

AU - Yamamoto, Kazuhide

PY - 2014

Y1 - 2014

N2 - Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.

AB - Hepatitis B virus (HBV) is one of the major viruses causing acute hepatitis. Recently, the incidence of acute hepatitis with genotype A has been increasing in Japan. The aim of this study was to investigate acute hepatitis B (AHB) in Okayama prefecture, with special attention to HBV genotype A. AHB patients who visited one of 12 general hospitals in Okayama prefecture between 2006 and 2010 were retrospectively analyzed. Over the course of the study period, 128 patients were diagnosed with AHB. Sexual transmission was supposed in the majority of patients (78 patients, 61%), including 59 (76%) having sex with heterosexual partners. The genotypes of HBV were assessed in 90 patients (70%), of whom 27 patients were infected with genotype A, 5 with genotype B, and 58 with genotype C. The prevalence of genotype A was significantly higher among male patients (28.7%), aged 20-29 (35.6%, p<0.01), among men who had sex with men (100%, p<0.005), and among patients having sex with unspecified partners (44.8%, p<0.005). Genotype A was not a significant factor associated with delayed HBsAg disappearance. Caution should be exercised with regard to sexually transmissible diseases in order to slow the pandemic spread of AHB due to genotype A.

KW - Acute hepatitis

KW - Hepatitis B virus

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M3 - Article

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AN - SCOPUS:84906729345

SN - 0386-300X

VL - 68

SP - 243

EP - 247

JO - Acta Medica Okayama

JF - Acta Medica Okayama

IS - 4

ER -

Prevalence and outcomes of acute hepatitis B in Okayama, Japan, 2006-2010

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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