TY - JOUR
T1 - Prevalence of albuminuria and renal dysfunction, and related clinical factors in Japanese patients with diabetes
T2 - The Japan Diabetes Complication and its Prevention prospective study 5
AU - the JDCP study group
AU - Shikata, Kenichi
AU - Kodera, Ryo
AU - Utsunomiya, Kazunori
AU - Koya, Daisuke
AU - Nishimura, Rimei
AU - Miyamoto, Satoshi
AU - Tajima, Naoko
N1 - Funding Information:
The JDCP study was supported by a grant‐in‐aid from the Ministry of Health, Labor and Welfare, Japan Diabetes Society, and the Manpei Suzuki Diabetes Foundation. The JDCP study investigators thank all diabetes patients who participated in this study, and to all physicians and medical staff at the 464 institutions.
Funding Information:
The JDCP study was supported by a grant-in-aid from the Ministry of Health, Labor and Welfare, Japan Diabetes Society, and the Manpei Suzuki Diabetes Foundation. The JDCP study investigators thank all diabetes patients who participated in this study, and to all physicians and medical staff at the 464 institutions.
Publisher Copyright:
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Aims/Introduction: To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the baseline data of the Japan Diabetes Complication and its Prevention prospective study. Materials and Methods: We used the data of 355 patients with type 1 diabetes and 5,194 patients with type 2 diabetes to evaluate the prevalence of albuminuria and renal dysfunction, and related factors. A binomial logistic regression analysis was used to investigate independent contributing factors for estimated glomerular filtration rate <60 mL/min/1.73 m2 or albuminuria. Results: The prevalence of microalbuminuria and macroalbuminuria was 15.2% (54/355) and 3.1% (11/355) in type 1 diabetes patients, and 25.0% (1,298/5,194) and 5.1% (265/5,194) in type 2 diabetes patients, respectively. The proportion of renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2) was 9.9% (35/355) in type 1 diabetes patients, and 15.3% (797/5,194) in type 2 diabetes patients. The proportion of patients with renal dysfunction with normoalbuminuria was 7.3% (26/355) for type 1 diabetes patients, and 9.0% (467/5,194) for type 2 diabetes patients. The factors related to albuminuria in type 2 diabetes patients were glycated hemoglobin, hypertension, age, duration of diabetes, body mass index and estimated glomerular filtration rate. In contrast, factors to related renal dysfunction were age, duration of diabetes, dyslipidemia, hypertension, body mass index, male sex and albuminuria. Conclusions: We showed the recent prevalence of albuminuria and renal dysfunction, and related factors in Japanese type 1 and type 2 diabetes patients using the baseline data of the Japan Diabetes Complication and its Prevention prospective study. The current results suggest that renal disease in patients with type 2 diabetes is heterogeneous, and different mechanisms might be involved in albuminuria and deterioration of renal function.
AB - Aims/Introduction: To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the baseline data of the Japan Diabetes Complication and its Prevention prospective study. Materials and Methods: We used the data of 355 patients with type 1 diabetes and 5,194 patients with type 2 diabetes to evaluate the prevalence of albuminuria and renal dysfunction, and related factors. A binomial logistic regression analysis was used to investigate independent contributing factors for estimated glomerular filtration rate <60 mL/min/1.73 m2 or albuminuria. Results: The prevalence of microalbuminuria and macroalbuminuria was 15.2% (54/355) and 3.1% (11/355) in type 1 diabetes patients, and 25.0% (1,298/5,194) and 5.1% (265/5,194) in type 2 diabetes patients, respectively. The proportion of renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2) was 9.9% (35/355) in type 1 diabetes patients, and 15.3% (797/5,194) in type 2 diabetes patients. The proportion of patients with renal dysfunction with normoalbuminuria was 7.3% (26/355) for type 1 diabetes patients, and 9.0% (467/5,194) for type 2 diabetes patients. The factors related to albuminuria in type 2 diabetes patients were glycated hemoglobin, hypertension, age, duration of diabetes, body mass index and estimated glomerular filtration rate. In contrast, factors to related renal dysfunction were age, duration of diabetes, dyslipidemia, hypertension, body mass index, male sex and albuminuria. Conclusions: We showed the recent prevalence of albuminuria and renal dysfunction, and related factors in Japanese type 1 and type 2 diabetes patients using the baseline data of the Japan Diabetes Complication and its Prevention prospective study. The current results suggest that renal disease in patients with type 2 diabetes is heterogeneous, and different mechanisms might be involved in albuminuria and deterioration of renal function.
KW - Diabetic kidney disease
KW - Diabetic nephropathy
KW - Japan Diabetes Complication and its Prevention study
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U2 - 10.1111/jdi.13116
DO - 10.1111/jdi.13116
M3 - Article
C2 - 31317670
AN - SCOPUS:85074386524
SN - 2040-1116
VL - 11
SP - 325
EP - 332
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 2
ER -
