TY - JOUR
T1 - Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder
AU - Honda, Tomoyuki
AU - Sofuku, Kozue
AU - Matsunaga, Hidenori
AU - Tachibana, Masaya
AU - Mohri, Ikuko
AU - Taniike, Masako
AU - Tomonaga, Keizo
N1 - Funding Information:
This study was supported in part by JSPS KAKENHI Grant Numbers JP24115709, JP25115508, JP25860336 and JP18H02664 and grants from the Takeda Science Foundation, Shimizu Foundation for Immunology and Neuroscience Grant for 2015, and Joint Usage/Research Center program of Institute for Frontier Life and Medical Sciences, Kyoto University (T.H.).
Publisher Copyright:
© 2018 The Societies and John Wiley & Sons Australia, Ltd
PY - 2018/7
Y1 - 2018/7
N2 - Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus-specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline-data for future studies regarding bornavirus epidemiology in children.
AB - Bornavirus infection occurs in many animals, including humans. However, the epidemiology of bornavirus in humans, especially children, is as yet unclear. Here, antibodies against bornaviruses in Japanese children with autism spectrum disorder (ASD) were evaluated using immunofluorescence analysis, western blotting and radio ligand assay. The prevalence of antibodies against bornavirus-specific speckles, nucleoprotein and phosphoprotein were 22%, 48%, and 33%, respectively, in children with ASD. According to our criteria, the prevalence of antibodies against bornaviruses was 7.4% in children with ASD. This is the first report of the serological prevalence of bornavirus in Japanese children. Our results provide valuable baseline-data for future studies regarding bornavirus epidemiology in children.
KW - antibody
KW - autism
KW - bornavirus
KW - epidemiology
UR - http://www.scopus.com/inward/record.url?scp=85050238423&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050238423&partnerID=8YFLogxK
U2 - 10.1111/1348-0421.12603
DO - 10.1111/1348-0421.12603
M3 - Article
AN - SCOPUS:85050238423
SN - 0385-5600
VL - 62
SP - 473
EP - 476
JO - Microbiology and Immunology
JF - Microbiology and Immunology
IS - 7
ER -