Prevalence of Antibody against Non‐A, non‐B Hepatitis Virus in Japanese Patients with Hepatocellular Carcinoma

Showgo Ohkoshi, Hideo Kojima, Hironobu Tawaraya, Tohru Miyajima, Tomoteru Kamimura, Hitoshi Asakura, Akira Satoh, Shinichi Hirose, Makoto Hijikata, Nobuyuki Kato, Kunitada Shimotohno

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89 Citations (Scopus)


Antibodies against a possible causative agent of non‐A, non‐B hepatitis, hepatitis C virus (HCV), in Japanese patients with hepatocellular carcinoma were analyzed using the enzyme‐linked immunosorbent assay (ELISA) system from Ortho Diagnostic Systems, Japan. Fifty of 58 cases of hepatitis B virus surface antigen (HBsAg)‐negative hepatocellular carcinoma were positive for the antibody (86%) and 8 of 42 cases of HBsAg‐positive hepatocellular carcinoma were positive (19%). Among patients with HBsAg‐negative hepatocellular carcinoma, the prevalence of the antibody was greater among those who had received a blood transfusion (97%) than among those with no history of transfusion (70%). Only 3 of 54 patients with cancers other than hepatocellular carcinoma were found to be antibody‐positive (5.6%) and all three patients had a history of blood transfusion. These results show a close relationship between the presence of anti‐HCV antibody and HBsAg‐negative hepatocellular carcinoma in Japan.

Original languageEnglish
Pages (from-to)550-553
Number of pages4
JournalJapanese Journal of Cancer Research
Issue number6-7
Publication statusPublished - Jun 1990
Externally publishedYes


  • Antibody
  • Hepatitis C virus
  • Hepatocellular carcinoma
  • Non‐A, non‐B hepatitis virus

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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