Preventing autoimmune and infection triggered atherosclerosis for an enduring healthful lifestyle

Eiji Matsuura, Kazuko Kobayashi, Luis R. Lopez

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Atherosclerosis is a chronic inflammatory disease of the arteries associated with various risk factors that promote lipid abnormalities (i.e., dyslipidemia), development and progression of atherosclerotic lesions, plaque rupture, and vascular thrombosis. Experimental evidence from biochemical and clinical studies support the idea that arterial thrombosis is an autoimmune process resulting from 'autoantibody'-mediated pro-atherogenic mechanisms now seen in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). In addition, it has been shown that persistent infections of Clamydia pneumoniae (C. pneumoniae), Porphyromonas gingivalis (P. gingivalis), and Helicobacter pylori (H. pylori) cause immune responses (infectious immunity) in their hosts that promote atherogenesis. In this article, we review recent progress in our understanding of immune- and infection-mediated atherosclerosis.

Original languageEnglish
Pages (from-to)214-222
Number of pages9
JournalAutoimmunity Reviews
Issue number3
Publication statusPublished - Jan 2008


  • Antiphospholipid syndrome (APS)
  • Atherosclerosis
  • Infection
  • Oxidized LDL (oxLDL)
  • β2-glycoprotein I (β2GPI)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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