Abstract
The effect of PN200-110, a novel calcium antagonist, on the formation of brain edema was examined with rats using a middle cerebral artery (MCA) occlusion model. PN200-110 was effective in preventing the formation of brain edema in 6-h ischemia and in 3-h reperfusion following 3-h ischemia, which were cases in which great accumulations of calcium were autoradiographically observed. Furthermore, PN200-110 diminished the excessive accumulation of calcium in the MCA area involved. These results indicate that an inhibition of the massive influx of calcium into brain cells by PN200-110 may partially ameliorate cell damage, resulting in prevention of brain edema.
| Original language | English |
|---|---|
| Pages (from-to) | 436-439 |
| Number of pages | 4 |
| Journal | Journal of Cerebral Blood Flow and Metabolism |
| Volume | 8 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1988 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cardiology and Cardiovascular Medicine