Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders

Akira Shimada, Yasuhide Hayashi, Mizuho Ogasawara, Myoung ja Park, Masahiko Katoh, Hisanori Minakami, Toshiyuki Kitoh, Seiji Kojima, Keisei Kawa, Hirokazu Kimura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1β [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p = 0.034], TNF-α [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p = 0.041], and IFN-γ [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p = 0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.

Original languageEnglish
Pages (from-to)1199-1203
Number of pages5
JournalLeukemia Research
Issue number9
Publication statusPublished - Sept 2007
Externally publishedYes


  • Acute megakaryoblastic leukaemia
  • Down syndrome
  • Pro-inflammatory cytokine
  • Transient abnormal myelopoiesis

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research


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