TY - JOUR
T1 - Pro-inflammatory cytokinemia is frequently found in Down syndrome patients with hematological disorders
AU - Shimada, Akira
AU - Hayashi, Yasuhide
AU - Ogasawara, Mizuho
AU - Park, Myoung ja
AU - Katoh, Masahiko
AU - Minakami, Hisanori
AU - Kitoh, Toshiyuki
AU - Kojima, Seiji
AU - Kawa, Keisei
AU - Kimura, Hirokazu
PY - 2007/9
Y1 - 2007/9
N2 - Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1β [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p = 0.034], TNF-α [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p = 0.041], and IFN-γ [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p = 0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.
AB - Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1β [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p = 0.034], TNF-α [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p = 0.041], and IFN-γ [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p = 0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.
KW - Acute megakaryoblastic leukaemia
KW - Down syndrome
KW - Pro-inflammatory cytokine
KW - Transient abnormal myelopoiesis
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UR - http://www.scopus.com/inward/citedby.url?scp=34249898927&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2006.09.008
DO - 10.1016/j.leukres.2006.09.008
M3 - Article
C2 - 17055049
AN - SCOPUS:34249898927
SN - 0145-2126
VL - 31
SP - 1199
EP - 1203
JO - Leukemia Research
JF - Leukemia Research
IS - 9
ER -
