Processing of hepatitis C virus precursor polyprotein.

K. Shimotohno, M. Hijikata, Y. Tanji, T. Kaneko, S. Satoh, T. Tanaka, N. Kato

Research output: Contribution to journalReview articlepeer-review


To elucidate the possible involvement of hepatitis C virus protein in the development of hepatocellular carcinoma. viral proteins produced from the largest open reading frame of the viral genome were analyzed. The function of each protein in virus replication was also examined. Virus proteins are produced by proteolytic cleavage by cellular and virus encoded proteinases. One of the viral proteins is a phosphoprotein, and the degree of phosphorylation is regulated by another viral protein. This regulation of phosphorylation may play an important role in modulating the proliferation of virus-infected cells.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalPrincess Takamatsu symposia
Publication statusPublished - 1995
Externally publishedYes


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