Production of a New Type of Bioactive Phenolic Compound

Akio Kobayashi, Yutaka Koguchi, Hiroshi Kanzaki, Ichiro Kajiyama, Kazuyoshi Kawazu

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Peroxidase (POD) catalyzed the polymerization of naturally occurring phenolics to give a variety of bioactive products. The guaiacol readily reacted in the POD system and afforded potential anti-microbial compounds. Three active phenols, 1, 2, and 3, were isolated from the reaction mixture. Spectroscopic analyses elucidated that 1 and 2 were a dimer and a trimer respectively originating from guaiacol. Compound 3 was readily oxidized to 4 by exposure to air. The structure of 4 was determined by a combination of chemical modification and spectroscopic analyses, and 3 was elucidated to be the hydroxyquinone form of 4.

Original languageEnglish
Pages (from-to)133-134
Number of pages2
JournalBioscience, biotechnology, and biochemistry
Issue number1
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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