TY - JOUR
T1 - Production of a New Type of Bioactive Phenolic Compound
AU - Kobayashi, Akio
AU - Koguchi, Yutaka
AU - Kanzaki, Hiroshi
AU - Kajiyama, Ichiro
AU - Kawazu, Kazuyoshi
N1 - Funding Information:
Acknowledgments. We are gratefUl to the SC-NMR Laboratory of Okayama University for 500 MHz experiments, to Dr. M. Hirota (Faculty of Agriculture, Shinshu University) for the assay, and to Toyobo Co. for presenting POD. This work was supported by a Grant-in-Aid to A.K. for Scientific Research (No. 04252104) from the Ministry of Education, Science, and Culture of Japan, and by a grant for Nagase Science and Technology Foundation.
PY - 1994
Y1 - 1994
N2 - Peroxidase (POD) catalyzed the polymerization of naturally occurring phenolics to give a variety of bioactive products. The guaiacol readily reacted in the POD system and afforded potential anti-microbial compounds. Three active phenols, 1, 2, and 3, were isolated from the reaction mixture. Spectroscopic analyses elucidated that 1 and 2 were a dimer and a trimer respectively originating from guaiacol. Compound 3 was readily oxidized to 4 by exposure to air. The structure of 4 was determined by a combination of chemical modification and spectroscopic analyses, and 3 was elucidated to be the hydroxyquinone form of 4.
AB - Peroxidase (POD) catalyzed the polymerization of naturally occurring phenolics to give a variety of bioactive products. The guaiacol readily reacted in the POD system and afforded potential anti-microbial compounds. Three active phenols, 1, 2, and 3, were isolated from the reaction mixture. Spectroscopic analyses elucidated that 1 and 2 were a dimer and a trimer respectively originating from guaiacol. Compound 3 was readily oxidized to 4 by exposure to air. The structure of 4 was determined by a combination of chemical modification and spectroscopic analyses, and 3 was elucidated to be the hydroxyquinone form of 4.
UR - https://www.scopus.com/pages/publications/85007961470
UR - https://www.scopus.com/pages/publications/85007961470#tab=citedBy
U2 - 10.1271/bbb.58.133
DO - 10.1271/bbb.58.133
M3 - Article
AN - SCOPUS:85007961470
SN - 0916-8451
VL - 58
SP - 133
EP - 134
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 1
ER -