Production of a novel percutaneous device realizing of prevention of germ infection made of a nono-scaled hydroxyapatite crystals/polymer composite

Nano-scale hydroxyapatite(HAp) crystals were covalently bonded to the surface of the silk fibroin(SF) substrate through poly(MTPS) grafting on the substrate. A button-form percutaneous device was fabricated by transplanting the HAp/SF composite fibers onto the surface of a button made from a silicone compound via an adhesive. The device was white and had good flexibility. Cells were able to penetrate into the space among the composite fibers in three-dimensional tangle. Soft tissue is expected to behave in a manner similar to the penetration of the cells into the device. Animal experiments with a percutaneous implantation of the button-form device for short to long period will be reported in this conference.