Prognostic significance of preexisting interstitial lung disease in Japanese patients with small-cell lung cancer

Yosuke Togashi, Katsuhiro Masago, Tomohiro Handa, Kiminobu Tanizawa, Chiyuki Okuda, Yuichi Sakamori, Hiroki Nagai, Young Hak Kim, Michiaki Mishima

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Background: In Japan, iatrogenic acute exacerbation of interstitial lung disease (ILD) is a serious complication in patients with lung cancer and simultaneous ILD. Results of some reports suggest that patients with ILD and small-cell lung cancer (SCLC) might benefit from chemotherapy, but the influence of ILD on prognosis is unclear. Patients and Methods: Retrospective study of patients with SCLC with or without ILD. Between April 2006 and March 2011, 122 patients with SCLC who were receiving platinum-based combination chemotherapy participated. Results: Twenty-eight patients (23.0%) had ILD at diagnosis. Pneumonitis associated with chemotherapy, including acute exacerbation-ILD was significantly increased in patients with preexisting ILD (8/28 vs. 2/94; P =.0001). In patients receiving chemotherapy alone, response rates and median progression-free survival of first-line chemotherapy in patients with or without preexisting ILD was not significantly different (P =.26; 20/26 vs. 52/60 and P =.089; 4.4 months vs. 5.4 months, respectively). The median overall survival of all patients was 15.5 months, but those without preexisting ILD survived significantly longer (P =.0010; 17.8 months vs. 10.7 months). Multivariate analysis revealed that performance status of 0 or 1 (hazard ratio [HR] 0.19 [95% confidence interval {CI}, 0.10-0.37]; P <.0001) limited disease (HR 0.42 [95% CI, 0.23-0.73]; P =.0017), and no preexisting ILD (HR 0.36 [95% CI, 0.19-0.69]; P =.0027) were significantly associated with longer overall survival. Conclusion: Patients with SCLC and ILD might benefit from chemotherapy, but preexisting ILD is an independent prognostic factor for poorer survival.

Original languageEnglish
Pages (from-to)304-311
Number of pages8
JournalClinical Lung Cancer
Issue number4
Publication statusPublished - Jul 2012
Externally publishedYes


  • Acute exacerbation
  • Chemotherapy
  • Idiopathic pulmonary fibrosis
  • Interstitial lung disease
  • Small-cell lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research


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