Programmed cell death in the developing epithelium of the mouse inner ear

Kazunori Nishizaki, Matti Anniko, Yorihisa Orita, Kenji Karita, Yu Masuda, Tadashi Yoshino

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Programmed cell death is as essential to development as is proliferation. Thus, the objective of this study was to elucidate the spatiotemporal involvement of programmed cell death in the development of the inner ear epithelia. Programmed cell death is seen in situ as apoptosis. A time-sequence study was performed on the distribution of apoptosis during the development of the inner ear epithelia of the mouse using the TdT-mediated dUTP-biotin nick labeling (TUNEL) method to detect apoptosis histochemically. Apoptosis occurred during the early stages of development of the inner ear and took place earlier in the organs of equilibrium than in the cochlea. These periods corresponded to those of active proliferation of epithelial cells in the inner ear. Since cell-cell interactions change after the removal of neighboring cells by apoptosis, apoptosis may influence cytodifferentiation.

Original languageEnglish
Pages (from-to)96-100
Number of pages5
JournalActa Oto-Laryngologica
Issue number1
Publication statusPublished - 1998


  • Apoptosis
  • Development
  • Epithelium
  • Inner ear
  • Mouse
  • Programmed cell death

ASJC Scopus subject areas

  • Otorhinolaryngology


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