Prolactin

Yoko Yamaguchi; Tatsuya Sakamoto

doi:10.1016/B978-0-12-820649-2.00054-1

Prolactin

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The classical PRL (PRL1) is best known for its role in enabling female mammals to produce milk. However, it is influential over a large number of functions; more than 300 separate actions of PRL1 have been reported in various vertebrates. Control of water and salt balance is an important function, especially in teleost fish. PRL1 universally acts in an endocrine, autocrine, and paracrine manner through the PRL receptor (PRLR) that belongs to the class I cytokine receptor family. PRL1 has important cell turnover-related functions and acts as growth, differentiating, and antiapoptotic factors, especially in hematopoiesis, angiogenesis, and the immune system through several pathways. PRL2 is structurally related to PRL1 and is able to activate PRLR; however, the function of PRL2 is largely unknown.

Original language	English
Title of host publication	Handbook of Hormones
Subtitle of host publication	Comparative Endocrinology for Basic and Clinical Research
Publisher	Elsevier
Pages	203-205
Number of pages	3
ISBN (Electronic)	9780128206492
DOIs	https://doi.org/10.1016/B978-0-12-820649-2.00054-1
Publication status	Published - Jan 1 2021

Keywords

Body fluid regulation
Cytokine
Dopamine
Immune system
JAK/STAT pathway
Lactation
Pit-1
Pituitary
Reproduction

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1016/B978-0-12-820649-2.00054-1

Cite this

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abstract = "The classical PRL (PRL1) is best known for its role in enabling female mammals to produce milk. However, it is influential over a large number of functions; more than 300 separate actions of PRL1 have been reported in various vertebrates. Control of water and salt balance is an important function, especially in teleost fish. PRL1 universally acts in an endocrine, autocrine, and paracrine manner through the PRL receptor (PRLR) that belongs to the class I cytokine receptor family. PRL1 has important cell turnover-related functions and acts as growth, differentiating, and antiapoptotic factors, especially in hematopoiesis, angiogenesis, and the immune system through several pathways. PRL2 is structurally related to PRL1 and is able to activate PRLR; however, the function of PRL2 is largely unknown.",

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AU - Sakamoto, Tatsuya

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KW - Body fluid regulation

KW - Cytokine

KW - Dopamine

KW - Immune system

KW - JAK/STAT pathway

KW - Lactation

KW - Pit-1

KW - Pituitary

KW - Reproduction

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BT - Handbook of Hormones

PB - Elsevier

ER -

Prolactin

Abstract

Keywords

ASJC Scopus subject areas

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