Yoko Yamaguchi, Tatsuya Sakamoto

Research output: Chapter in Book/Report/Conference proceedingChapter


The classical PRL (PRL1) is best known for its role in enabling female mammals to produce milk. However, it is influential over a large number of functions; more than 300 separate actions of PRL1 have been reported in various vertebrates. Control of water and salt balance is an important function, especially in teleost fish. PRL1 universally acts in an endocrine, autocrine, and paracrine manner through the PRL receptor (PRLR) that belongs to the class I cytokine receptor family. PRL1 has important cell turnover-related functions and acts as growth, differentiating, and antiapoptotic factors, especially in hematopoiesis, angiogenesis, and the immune system through several pathways. PRL2 is structurally related to PRL1 and is able to activate PRLR; however, the function of PRL2 is largely unknown.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
Number of pages3
ISBN (Electronic)9780128206492
Publication statusPublished - Jan 1 2021


  • Body fluid regulation
  • Cytokine
  • Dopamine
  • Immune system
  • JAK/STAT pathway
  • Lactation
  • Pit-1
  • Pituitary
  • Reproduction

ASJC Scopus subject areas

  • Medicine(all)


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