Prolactin-releasing peptide

Tetsuya Tachibana, Tatsuya Sakamoto

Research output: Chapter in Book/Report/Conference proceedingChapter


Prolactin-releasing peptide (PrRP), an RFamide peptide, had been originally identified as a stimulator of prolactin release from the anterior pituitary. However, further studies revealed that the prolactin-releasing effect of PrRP is inconsistent and different from ordinary hypophysiotropic hormones. However, PrRP is demonstrated to have some physiological roles, such as inhibition of feeding, obesity, and stress response, and control of the release of hypothalamic hormones in mammals. On the other hand, PrRP2 (C-RFa) has been identified as a neuropeptide that originates from a common ancestral gene of PrRP. PrRP2 is found in vertebrates except for mammals. PrRP2 is a potent stimulator of prolactin in teleosts, but has a lesser effect in amphibians and chickens. As in PrRP, PrRP2 is related to energy homeostasis in teleosts and chickens. The physiological functions of PrRP and PrRP2 may have changed through evolution.

Original languageEnglish
Title of host publicationHandbook of Hormones
Subtitle of host publicationComparative Endocrinology for Basic and Clinical Research
Number of pages4
ISBN (Electronic)9780128206492
Publication statusPublished - Jan 1 2021


  • Feeding and stress response
  • Obesity
  • Prolactin
  • PrRP
  • PrRP-2
  • RFamide

ASJC Scopus subject areas

  • General Medicine


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