Proliferating cell nuclear antigen and grade of malignancy in small hepatocellular carcinoma evaluation in US-guided specimens

N. Hino, T. Higashi, K. Nouso, H. Nakatsukasa, Y. Urabe, N. Kinugasa, K. Yoshida, K. Ashida, S. Ohguchi, T. Tsuji

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Background/Aims: We investigated the value of the proliferating cell nuclear antigen labeling index ratio (PCNA-LI ratio: PCNA-LI of cancer / PCNA-LI of surrounding non-cancerous liver tissue) to clarify the prognosis of the patients bearing small hepatocellular carcinomas (HCC) less than 20 mm in diameter and treated by percutaneous ethanol injection therapy (PEIT). Material and Methods: Twenty eight HCC patients who had received PEIT were divided into 3 groups. The non-recurrence (NR) group in, which no new lesions were observed for at least 18 months after PEIT (13 patients), the early recurrence group (ER) in which lesions recurred within one year (6 patients), anal the late recurrence group (LR) in which lesions recurred more than one year after PEIT (9 patients). Immunohistochemical staining of PCNA was done using biopsied specimens. Results: The PCNA-LI ratio in 37 well differentiated, 13 moderately differentiated 11 poorly differentiated HCC were 1.86 ± 0.55, 3.33 ± 0.51, and 4.75 ± 0.81 (mean ± SD), respectively. The ratio in. ER group (4.57 ± 0.57) was significantly higher than that in. LR (2.04 ± 0.61) and NR group (1.87 ± 0.62) and the PCNA-LI ratio tended to correlate with the periods until the development of recurrent lesions in, cases of ER group. Conclusions: These results indicate the PCNA-LI ratio, in conjunction with the histological grade, is a useful marker for evaluating the grade of malignancy, and for predicting the period until recurrence after treatment of small HCC.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
Issue number13
Publication statusPublished - Mar 11 1997


  • Hepatocellular carcinoma
  • PCNA
  • Recurrence

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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