TY - JOUR
T1 - Proliferation of Hepatocytes and Attenuation from Carbon Tetrachloride Hepatotoxicity by Gadolinium Chloride in Rats
AU - Ishiyama, Hironobu
AU - Sato, Makoto
AU - Matsumura, Kuniko
AU - Sento, Miwa
AU - Ogino, Keiki
AU - Hobara, Tatsuya
PY - 1995/10
Y1 - 1995/10
N2 - Abstract: Intravenous injection of gadolinium chloride (GdCl3) at a dose of 10 mg/kg caused an increase in proliferating cell nuclear antigen labeling index and the grade of pyronin positivity (RNA level) in rat liver. In CCl4‐exposed rats, pretreatment with GdCl3 also showed a preventive effect of the liver injury both biochemically and histologically. Moreover, the proliferative action preceded the attenuative effect of the liver injury. Results suggest that GdCl3 induces hepatocyte proliferation, and this action of GdCl3 may modify the development of CCl4‐induced liver injury. 1995 Nordic Pharmacological Society
AB - Abstract: Intravenous injection of gadolinium chloride (GdCl3) at a dose of 10 mg/kg caused an increase in proliferating cell nuclear antigen labeling index and the grade of pyronin positivity (RNA level) in rat liver. In CCl4‐exposed rats, pretreatment with GdCl3 also showed a preventive effect of the liver injury both biochemically and histologically. Moreover, the proliferative action preceded the attenuative effect of the liver injury. Results suggest that GdCl3 induces hepatocyte proliferation, and this action of GdCl3 may modify the development of CCl4‐induced liver injury. 1995 Nordic Pharmacological Society
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U2 - 10.1111/j.1600-0773.1995.tb01030.x
DO - 10.1111/j.1600-0773.1995.tb01030.x
M3 - Article
C2 - 8577643
AN - SCOPUS:0028871555
SN - 0901-9928
VL - 77
SP - 293
EP - 298
JO - Pharmacology & Toxicology
JF - Pharmacology & Toxicology
IS - 4
ER -