TY - GEN
T1 - Prompt gamma tomography for BNCT-SPECT
T2 - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018
AU - Fatemi, S.
AU - Bortolussi, S.
AU - Magni, C.
AU - Postuma, I.
AU - Bettelli, M.
AU - Benassi, G.
AU - Zambelli, N.
AU - Zappettini, A.
AU - Altieri, S.
AU - Protti, N.
N1 - Funding Information:
The present study has been supported by NETTUNO and 3CaTS project funded by the Italian National Institute of Nuclear Physics INFN.
Funding Information:
ACKNOWLEDGMENT The present study has been supported by NETTUNO and 3CaTS project funded by the Italian National Institute of Nuclear Physics INFN.
Publisher Copyright:
© 2018 IEEE.
PY - 2018/11
Y1 - 2018/11
N2 - Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the reaction 10B(n,α)7Li induced by thermal neutrons. 10B selectively loads cancer cells through a boronated drug injected into patient few hours before neutron irradiation. The secondary charged particles have short ranges in tissues (less than the mean cell diameter of few tens of μm), thus they deposit their whole kinetic energy (up to 2.79 MeV) inside the cell where the capture reaction took place. In this way it is possible to selectively damage the malignant cells sparing the surrounding healthy ones.To take full advantage of BNCT selectivity a precise knowledge of 10B spatial distribution is required. This quantity can be measured by Single Photon Emission Computed Tomography (SPECT) thanks to the emission of a 478 keV γ ray in the 94% of 10B capture reactions. Notably, the counting rate of this photon is meaningful of the dose rate due to the neutron captures in the patient thus allowing an in vivo, real time dose monitoring.In the present study we evaluated the capabilities of a small prototype of CdZnTe (CZT) photon detector to reconstruct the tomographic image of tissue equivalent phantoms loaded with point like γ sources (such as 22Na, 137Cs and 57Co), activated detectors (Cu and Au wires) and 18F water solutions.
AB - Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the reaction 10B(n,α)7Li induced by thermal neutrons. 10B selectively loads cancer cells through a boronated drug injected into patient few hours before neutron irradiation. The secondary charged particles have short ranges in tissues (less than the mean cell diameter of few tens of μm), thus they deposit their whole kinetic energy (up to 2.79 MeV) inside the cell where the capture reaction took place. In this way it is possible to selectively damage the malignant cells sparing the surrounding healthy ones.To take full advantage of BNCT selectivity a precise knowledge of 10B spatial distribution is required. This quantity can be measured by Single Photon Emission Computed Tomography (SPECT) thanks to the emission of a 478 keV γ ray in the 94% of 10B capture reactions. Notably, the counting rate of this photon is meaningful of the dose rate due to the neutron captures in the patient thus allowing an in vivo, real time dose monitoring.In the present study we evaluated the capabilities of a small prototype of CdZnTe (CZT) photon detector to reconstruct the tomographic image of tissue equivalent phantoms loaded with point like γ sources (such as 22Na, 137Cs and 57Co), activated detectors (Cu and Au wires) and 18F water solutions.
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U2 - 10.1109/NSSMIC.2018.8824421
DO - 10.1109/NSSMIC.2018.8824421
M3 - Conference contribution
AN - SCOPUS:85073114054
T3 - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
BT - 2018 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2018 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 10 November 2018 through 17 November 2018
ER -
