Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction

Hideo K. Takahashi; Dong Xue; Hiromi Iwagaki; Ryuji Tamura; Goutarou Katsuno; Takahito Yagi; Tadashi Yoshino; Shuji Mori; Masahiro Nishibori; Noriaki Tanaka

doi:10.1016/j.clim.2004.12.001

Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction

Hideo K. Takahashi, Dong Xue, Hiromi Iwagaki, Ryuji Tamura, Goutarou Katsuno, Takahito Yagi, Tadashi Yoshino, Shuji Mori, Masahiro Nishibori, Noriaki Tanaka

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.

Original language	English
Pages (from-to)	85-92
Number of pages	8
Journal	Clinical Immunology
Volume	115
Issue number	1 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.clim.2004.12.001
Publication status	Published - Apr 2005

Keywords

Adhesion molecule
Human
IL-18
MLR
Prostaglandin

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.clim.2004.12.001

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@article{441acb1373a9474fbc2a18e7496b9f6c,

title = "Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction",

abstract = "Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.",

keywords = "Adhesion molecule, Human, IL-18, MLR, Prostaglandin",

author = "Takahashi, {Hideo K.} and Dong Xue and Hiromi Iwagaki and Ryuji Tamura and Goutarou Katsuno and Takahito Yagi and Tadashi Yoshino and Shuji Mori and Masahiro Nishibori and Noriaki Tanaka",

note = "Funding Information: The authors thank Ono Pharmaceutical Co. (Tokyo, Japan) for generously donating PGE1, ONO-1301, ONO-DI-004, ONO-AE1-259-01, ONO-AE-248, ONO-AE1-329, and ONO-AE3-208. This study was supported in part by a grant for the Promotion of Research from Okayama University (No. 21 to M.N.), a grant from the Okayama Medical Foundation (to H.K.T.) and by a Grant-in-Aid for Scientific Research (C) (15590467 to H.K.T. and 15590228 to M.N.). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2005",

month = apr,

doi = "10.1016/j.clim.2004.12.001",

language = "English",

volume = "115",

pages = "85--92",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

number = "1 SPEC. ISS.",

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TY - JOUR

T1 - Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction

AU - Takahashi, Hideo K.

AU - Xue, Dong

AU - Iwagaki, Hiromi

AU - Tamura, Ryuji

AU - Katsuno, Goutarou

AU - Yagi, Takahito

AU - Yoshino, Tadashi

AU - Mori, Shuji

AU - Nishibori, Masahiro

AU - Tanaka, Noriaki

N1 - Funding Information: The authors thank Ono Pharmaceutical Co. (Tokyo, Japan) for generously donating PGE1, ONO-1301, ONO-DI-004, ONO-AE1-259-01, ONO-AE-248, ONO-AE1-329, and ONO-AE3-208. This study was supported in part by a grant for the Promotion of Research from Okayama University (No. 21 to M.N.), a grant from the Okayama Medical Foundation (to H.K.T.) and by a Grant-in-Aid for Scientific Research (C) (15590467 to H.K.T. and 15590228 to M.N.). Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2005/4

Y1 - 2005/4

N2 - Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.

AB - Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.

KW - Adhesion molecule

KW - Human

KW - IL-18

KW - MLR

KW - Prostaglandin

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JO - Clinical Immunology

JF - Clinical Immunology

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ER -

Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction

Abstract

Keywords

ASJC Scopus subject areas

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