Proteases produced by vibrios

Sumio Shinoda, Shin Ichi Miyoshi

Research output: Contribution to journalShort surveypeer-review

49 Citations (Scopus)


Bacteria of the genus Vibrio are normal habitants of the aquatic environment but the some species are believed to be human pathogens. Pathogenic vibrios produce various pathogenic factors, and the proteases are also recognized to play pathogenic roles in the infection: the direct roles by digesting many kinds of host proteins or indirect roles by processing other pathogenic protein factors. Especially VVP from Vibrio vulnificus is thought to be a major pathogenic factor of the vibrio. Although HA/P, the V. cholerae hemagglutinin/protease, is not a direct toxic factor of cholera vibrio, its significance is an undeniable fact. Production of HA/P is regulated together with major pathogenic factors such as CT (cholera toxin) or TCP (toxin co-regulated pilus) by a quorum-sensing system. HA/P is necessary for full expression of pathogenicity of the vibrio by supporting growth and translocation in the digestive tract. Processing of protein toxins such as CT or EI Tor hemolysin is also an important pathogenic role.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalBiocontrol science
Issue number1
Publication statusPublished - Mar 10 2011


  • Metalloprotease
  • Protease
  • Vibrio

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Public Health, Environmental and Occupational Health


Dive into the research topics of 'Proteases produced by vibrios'. Together they form a unique fingerprint.

Cite this