Protective effect of carbon monoxide for organ injury

Atsunori Nakao, Eiji Kobayashi, Noriaki Tanaka, Noriko Murase

Research output: Contribution to journalReview articlepeer-review


Heme oxygenase (HO) catabolizes heme into three products: carbon monoxide (CO), biliverdin and free iron. HO-1, inducible form of HO, has been shown to be protective against various stress. CO at a low concentration has been shown to be protective in several disease models mimicking the action of HO-1. We suggest that CO, the byproduct of heme degradation, could be valuable therapeutic agents. We review the functional role of HO-1 and CO and its potential application to clinical settings.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalNippon Geka Gakkai zasshi
Issue number4
Publication statusPublished - Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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