Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP-32 and spinophilin

Zhen Yan; Linda Hsieh-Wilson; Jian Feng; Kazuhito Tomizawa; Patrick B. Allen; Allen A. Fienberg; Angus C. Nairn; Paul Greengard

doi:10.1038/4516

Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP-32 and spinophilin

Zhen Yan, Linda Hsieh-Wilson, Jian Feng, Kazuhito Tomizawa, Patrick B. Allen, Allen A. Fienberg, Angus C. Nairn, Paul Greengard

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247 Citations (Scopus)

Abstract

Modulation of AMPA-type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP-1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP-1 catalytic activity by DARPP-32, a dopamine- and cAMP-regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP-1 to spinophilin, a protein that colocalizes PP-1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP-1 is important for AMPA-receptor-mediated synaptic transmission and plasticity.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Nature Neuroscience
Volume	2
Issue number	1
DOIs	https://doi.org/10.1038/4516
Publication status	Published - Jan 1999

ASJC Scopus subject areas

Neuroscience(all)

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abstract = "Modulation of AMPA-type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP-1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP-1 catalytic activity by DARPP-32, a dopamine- and cAMP-regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP-1 to spinophilin, a protein that colocalizes PP-1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP-1 is important for AMPA-receptor-mediated synaptic transmission and plasticity.",

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AU - Yan, Zhen

AU - Hsieh-Wilson, Linda

AU - Feng, Jian

AU - Tomizawa, Kazuhito

AU - Allen, Patrick B.

AU - Fienberg, Allen A.

AU - Nairn, Angus C.

AU - Greengard, Paul

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AB - Modulation of AMPA-type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP-1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP-1 catalytic activity by DARPP-32, a dopamine- and cAMP-regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP-1 to spinophilin, a protein that colocalizes PP-1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP-1 is important for AMPA-receptor-mediated synaptic transmission and plasticity.

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Protein phosphatase 1 modulation of neostriatal AMPA channels: Regulation by DARPP-32 and spinophilin

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