Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

Dai Shimizu; Hiromasa Yamamoto; Kazuhiko Shien; Kohei Taniguchi; Kentaroh Miyoshi; Kei Namba; Kumi Mesaki; Seiichiro Sugimoto; Junichi Sou; Masaomi Yamane; Shinichi Toyooka

doi:10.18926/AMO/62819

Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

Dai Shimizu, Hiromasa Yamamoto, Kazuhiko Shien, Kohei Taniguchi, Kentaroh Miyoshi, Kei Namba, Kumi Mesaki, Seiichiro Sugimoto, Junichi Sou, Masaomi Yamane, Shinichi Toyooka

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.

Original language	English
Pages (from-to)	759-762
Number of pages	4
Journal	Acta medica Okayama
Volume	75
Issue number	6
DOIs	https://doi.org/10.18926/AMO/62819
Publication status	Published - Dec 1 2021

Keywords

next-generation sequencing
non-small cell lung cancer
non-V600E BRAF mutation
pulmonary adenocarcinoma with enteric differentiation
somatic mutations

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.18926/AMO/62819

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title = "Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation",

abstract = "Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.",

keywords = "next-generation sequencing, non-small cell lung cancer, non-V600E BRAF mutation, pulmonary adenocarcinoma with enteric differentiation, somatic mutations",

author = "Dai Shimizu and Hiromasa Yamamoto and Kazuhiko Shien and Kohei Taniguchi and Kentaroh Miyoshi and Kei Namba and Kumi Mesaki and Seiichiro Sugimoto and Junichi Sou and Masaomi Yamane and Shinichi Toyooka",

year = "2021",

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doi = "10.18926/AMO/62819",

language = "English",

volume = "75",

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journal = "Acta Medica Okayama",

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TY - JOUR

T1 - Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

AU - Shimizu, Dai

AU - Yamamoto, Hiromasa

AU - Shien, Kazuhiko

AU - Taniguchi, Kohei

AU - Miyoshi, Kentaroh

AU - Namba, Kei

AU - Mesaki, Kumi

AU - Sugimoto, Seiichiro

AU - Sou, Junichi

AU - Yamane, Masaomi

AU - Toyooka, Shinichi

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.

AB - Pulmonary enteric adenocarcinoma (PEAC) is a rare subtype of lung cancer that should be differentiated from colorectal cancer metastasis. Little is known about its genetic background. An 84-year-old male with adenocarcinoma of the lung underwent left upper lobectomy. The histology of the surgical specimen was suggestive of PEAC. Gastrointestinal and colorectal fiberscopy revealed no evidence of colorectal cancer. Next-generation sequencing of the tumor identified a G469V substitution in serine/threonine-protein kinase B-raf (BRAF). Based on the higher prevalence of the G469 substitution in BRAF-mutant lung adenocarcinoma than in BRAFmutant colorectal cancer, the tumor likely originated from the lung. Identification of mutational genotype may be of some help in distinguishing PEAC from the lung metastasis of colorectal cancer.

KW - next-generation sequencing

KW - non-small cell lung cancer

KW - non-V600E BRAF mutation

KW - pulmonary adenocarcinoma with enteric differentiation

KW - somatic mutations

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U2 - 10.18926/AMO/62819

DO - 10.18926/AMO/62819

M3 - Article

C2 - 34955547

AN - SCOPUS:85122906586

SN - 0386-300X

VL - 75

SP - 759

EP - 762

JO - Acta Medica Okayama

JF - Acta Medica Okayama

IS - 6

ER -

Pulmonary Enteric Adenocarcinoma Harboring a BRAF G469V Mutation

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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