Pulmonary involvement of acute myeloid leukemia mimicking transfusion-related acute lung injury

Kentaro Ido, Yasutaka Aoyama, Joji Nagasaki, Shiro Koh, Hiroyoshi Ichihara, Hiroshi Harada, Kiyoshi Kawano, Yoshihiko Tani, Nobuki Matsuyama, Fumiya Hirayama, Masatoshi Kohsaki, Shuji Takaku, Atsuko Mugitani

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Transfusion-related acute lung injury (TRALI) is defined as a new episode of acute lung injury (ALI) occurring during transfusion or within 6 hours of transfusion completion. A 66-year-old man suffering from acute myeloid leukemia developed acute respiratory distress syndrome after platelet transfusion. TRALI was diagnosed clinically, but an autopsy showed leukemic cells in diffuse pulmonary edema. Anti-human neutrophil antigen (HNA)-3a antibodies were detected in the donor serum, and the HNA-3 genotype of the patient was identified as a/a. This case was considered to represent pulmonary involvement of acute myeloid leukemia, rather than TRALI. A revision of the definition of TRALI accounting for hematological malignancies should therefore be considered.

Original languageEnglish
Pages (from-to)2493-2496
Number of pages4
JournalInternal Medicine
Issue number18
Publication statusPublished - 2017
Externally publishedYes


  • Acute myeloid leukemia
  • Autopsy
  • Transfusion-related acute lung injury

ASJC Scopus subject areas

  • Internal Medicine


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