Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis

Nobuaki Miyahara; Ryosuke Eda; Yoshiki Umemori; Tomoyuki Murakami; Naomi Kunichika; Kiyoshi Makihata; Keisuke Aoe; Kazuo Murakami; Hiroyasu Takeyama; Mine Harada

doi:10.2169/internalmedicine.40.786

Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis

Nobuaki Miyahara, Ryosuke Eda, Yoshiki Umemori, Tomoyuki Murakami, Naomi Kunichika, Kiyoshi Makihata, Keisuke Aoe, Kazuo Murakami, Hiroyasu Takeyama, Mine Harada

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.

Original language	English
Pages (from-to)	786-790
Number of pages	5
Journal	Internal Medicine
Volume	40
Issue number	8
DOIs	https://doi.org/10.2169/internalmedicine.40.786
Publication status	Published - Aug 2001

Keywords

Large-cell type
Lung
Non-Hodgkin's lymphoma

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.40.786

Cite this

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title = "Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis",

abstract = "A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.",

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AU - Miyahara, Nobuaki

AU - Eda, Ryosuke

AU - Umemori, Yoshiki

AU - Murakami, Tomoyuki

AU - Kunichika, Naomi

AU - Makihata, Kiyoshi

AU - Aoe, Keisuke

AU - Murakami, Kazuo

AU - Takeyama, Hiroyasu

AU - Harada, Mine

PY - 2001/8

Y1 - 2001/8

N2 - A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.

AB - A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.

KW - Large-cell type

KW - Lung

KW - Non-Hodgkin's lymphoma

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Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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