Pulmonary lymphoma of large B-cell type mimicking Wegener's granulomatosis

Nobuaki Miyahara, Ryosuke Eda, Yoshiki Umemori, Tomoyuki Murakami, Naomi Kunichika, Kiyoshi Makihata, Keisuke Aoe, Kazuo Murakami, Hiroyasu Takeyama, Mine Harada

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20 Citations (Scopus)


A 27-year-old man with a primary pulmonary lymphoma of large B-cell type is described. Symptoms involved both the upper and lower respiratory tract. A chest roentgenogram showed a dense mass with cavitation. Transbronchial biopsy specimens revealed no atypical cells, rather they demonstrated granulomatous infiltration and vasculitis consistent with but not conclusively diagnostic of Wegener's granulomatosis. The pulmonary mass became smaller after sulfamethoxazole-trimethoprim therapy. These features suggested Wegener's granulomatosis. However, an open biopsy specimen was diagnostic for diffuse lymphoma of large B-cell type. High-grade pulmonary lymphoma should be considered in the differential diagnosis of patients with clinical and pathologic features suggesting Wegener's granulomatosis.

Original languageEnglish
Pages (from-to)786-790
Number of pages5
JournalInternal Medicine
Issue number8
Publication statusPublished - Aug 2001


  • Large-cell type
  • Lung
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Internal Medicine


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