Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.

Keiko Hirano; Takaaki Kubota; Masashi Tsuda; Yuzuru Mikami; Jun'ichi Kobayashi

doi:10.1248/cpb.48.974

Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.

Keiko Hirano, Takaaki Kubota, Masashi Tsuda, Yuzuru Mikami, Jun'ichi Kobayashi

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.

Original language	English
Pages (from-to)	974-977
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	48
Issue number	7
DOIs	https://doi.org/10.1248/cpb.48.974
Publication status	Published - Jul 2000
Externally published	Yes

Keywords

Amphimedon sp.
Antimicrobial activity
Bis-pyridine alkaloids
Cytotoxicity
Sponge

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1248/cpb.48.974

Cite this

@article{d81b7c916d0942ac9440892b38c02bee,

title = "Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.",

abstract = "New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.",

keywords = "Amphimedon sp., Antimicrobial activity, Bis-pyridine alkaloids, Cytotoxicity, Sponge",

author = "Keiko Hirano and Takaaki Kubota and Masashi Tsuda and Yuzuru Mikami and Jun'ichi Kobayashi",

year = "2000",

month = jul,

doi = "10.1248/cpb.48.974",

language = "English",

volume = "48",

pages = "974--977",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "7",

}

TY - JOUR

T1 - Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.

AU - Hirano, Keiko

AU - Kubota, Takaaki

AU - Tsuda, Masashi

AU - Mikami, Yuzuru

AU - Kobayashi, Jun'ichi

PY - 2000/7

Y1 - 2000/7

N2 - New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.

AB - New bis-pyridine alkaloids, pyrinodemins B - D (1 - 3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5 - 8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B - D (1 - 3) showed potent cytotoxicity, while compounds 5 - 8 exhibited antimicrobial activity.

KW - Amphimedon sp.

KW - Antimicrobial activity

KW - Bis-pyridine alkaloids

KW - Cytotoxicity

KW - Sponge

UR - http://www.scopus.com/inward/record.url?scp=0033914530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033914530&partnerID=8YFLogxK

U2 - 10.1248/cpb.48.974

DO - 10.1248/cpb.48.974

M3 - Article

C2 - 10923825

AN - SCOPUS:0033914530

SN - 0009-2363

VL - 48

SP - 974

EP - 977

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 7

ER -

Pyrinodemins B - D, potent cytotoxic bis-pyridine alkaloids from marine sponge Amphimedon sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this