Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain

Yoshihisa Kurasawa; Kiminari Yoshida; Naoki Yamazaki; Eisuke Kaji; Kenji Sasaki; Yoshiko Hiwasa; Akiko Tsukamoto; Hideyuki Itoc

doi:10.1002/jhet.297

Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain

Yoshihisa Kurasawa, Kiminari Yoshida, Naoki Yamazaki, Eisuke Kaji, Kenji Sasaki, Yoshiko Hiwasa, Akiko Tsukamoto, Hideyuki Itoc

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.

Original language	English
Pages (from-to)	657-663
Number of pages	7
Journal	Journal of Heterocyclic Chemistry
Volume	47
Issue number	3
DOIs	https://doi.org/10.1002/jhet.297
Publication status	Published - May 2010

ASJC Scopus subject areas

Organic Chemistry

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title = "Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain",

abstract = "Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.",

author = "Yoshihisa Kurasawa and Kiminari Yoshida and Naoki Yamazaki and Eisuke Kaji and Kenji Sasaki and Yoshiko Hiwasa and Akiko Tsukamoto and Hideyuki Itoc",

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T2 - Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain

AU - Kurasawa, Yoshihisa

AU - Yoshida, Kiminari

AU - Yamazaki, Naoki

AU - Kaji, Eisuke

AU - Sasaki, Kenji

AU - Hiwasa, Yoshiko

AU - Tsukamoto, Akiko

AU - Itoc, Hideyuki

PY - 2010/5

Y1 - 2010/5

N2 - Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.

AB - Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.

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JO - Journal of Heterocyclic Chemistry

JF - Journal of Heterocyclic Chemistry

IS - 3

ER -

Quinolone analogues 10: Synthesis of antimalarial quinolones having pyridyl moiety in N1-side chain

Abstract

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