TY - JOUR
T1 - Quinolone analogues 12
T2 - Synthesis and tautomers of 2-substituted 4-quinolones and related compounds
AU - Kurasawa, Yoshihisa
AU - Yoshida, Kiminari
AU - Yamazaki, Naoki
AU - Iwamoto, Kotoji
AU - Hamamoto, Yoshihiko
AU - Kaji, Eisuke
AU - Sasaki, Kenji
AU - Zamami, Yoshito
PY - 2012/11
Y1 - 2012/11
N2 - The 4-quinolone-2-carboxylates 4a,b were converted into the 4-quinolone-2-carbohydrazides 5a,b, hydrazones 6,7,10, and related compounds 8,9,11. The 4-methoxyquinoline-2-carboxylate 12 was also transformed into the 4-methoxyquinoline-2-carbohydrazide 13, which was modified to the hydrazone 14 and related compound 15. The antimicrobial activities of compounds 6b and 14 are described together with the 4-oxo and 4-hydroxy tautomers of compounds 4-11 in deuteriodimethyl sulfoxide and deuteriotrifluoroacetic acid.
AB - The 4-quinolone-2-carboxylates 4a,b were converted into the 4-quinolone-2-carbohydrazides 5a,b, hydrazones 6,7,10, and related compounds 8,9,11. The 4-methoxyquinoline-2-carboxylate 12 was also transformed into the 4-methoxyquinoline-2-carbohydrazide 13, which was modified to the hydrazone 14 and related compound 15. The antimicrobial activities of compounds 6b and 14 are described together with the 4-oxo and 4-hydroxy tautomers of compounds 4-11 in deuteriodimethyl sulfoxide and deuteriotrifluoroacetic acid.
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U2 - 10.1002/jhet.922
DO - 10.1002/jhet.922
M3 - Article
AN - SCOPUS:84870894149
SN - 0022-152X
VL - 49
SP - 1323
EP - 1331
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
IS - 6
ER -