Radical hydroxyalkylation of C-H bond adjacent to nitrogen of tertiary amides, ureas, and amines

Takehiko Yoshimitsu; Yoshimasa Arano; Hiroto Nagaoka

doi:10.1021/ja053855q

Radical hydroxyalkylation of C-H bond adjacent to nitrogen of tertiary amides, ureas, and amines

Takehiko Yoshimitsu, Yoshimasa Arano, Hiroto Nagaoka

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the Et₃B/air conditions, thereby providing a unique and simple means for the radical sp³ C-H transformation of nitrogen-containing molecules.

Original language	English
Pages (from-to)	11610-11611
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	33
DOIs	https://doi.org/10.1021/ja053855q
Publication status	Published - Aug 24 2005
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja053855q

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abstract = "Tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the Et3B/air conditions, thereby providing a unique and simple means for the radical sp3 C-H transformation of nitrogen-containing molecules.",

author = "Takehiko Yoshimitsu and Yoshimasa Arano and Hiroto Nagaoka",

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AU - Yoshimitsu, Takehiko

AU - Arano, Yoshimasa

AU - Nagaoka, Hiroto

PY - 2005/8/24

Y1 - 2005/8/24

N2 - Tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the Et3B/air conditions, thereby providing a unique and simple means for the radical sp3 C-H transformation of nitrogen-containing molecules.

AB - Tertiary amides, ureas, and amines undergo direct intermolecular addition to aldehydes under the Et3B/air conditions, thereby providing a unique and simple means for the radical sp3 C-H transformation of nitrogen-containing molecules.

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JF - Journal of the American Chemical Society

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Radical hydroxyalkylation of C-H bond adjacent to nitrogen of tertiary amides, ureas, and amines

Abstract

ASJC Scopus subject areas

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