Radionuclide imaging of neurohormonal system of the heart

Xinyu Chen, Rudolf A. Werner, Mehrbod S. Javadi, Yoshifumi Maya, Michael Decker, Constantin Lapa, Ken Herrmann, Takahiro Higuchi

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Heart failure is one of the growing causes of death especially in developed countries due to longer life expectancy. Although many pharmacological and instrumental therapeutic approaches have been introduced for prevention and treatment of heart failure, there are still limitations and challenges. Nuclear cardiology has experienced rapid growth in the last few decades, in particular the application of single photon emission computed tomography (SPECT) and positron emission tomography (PET), which allow non-invasive functional assessment of cardiac condition including neurohormonal systems involved in heart failure; its application has dramatically improved the capacity for fundamental research and clinical diagnosis. In this article, we review the current status of applying radionuclide technology in non-invasive imaging of neurohormonal system in the heart, especially focusing on the tracers that are currently available. A short discussion about disadvantages and perspectives is also included.

Original languageEnglish
Pages (from-to)545-558
Number of pages14
Issue number6
Publication statusPublished - 2015
Externally publishedYes


  • Cardiac neurohormonal system
  • Heart failure
  • Nuclear cardiology
  • PET
  • Radiotracer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)


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