Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain

Hsi hsien Chou; Norio Ogawa; Masato Asanuma; Hiroshi Hirata; Yoichi Kondo; Akitane Mori

doi:10.1016/0169-328X(93)90028-N

Rapid response of striatal muscarinic M₁-receptor mRNA to muscarinic cholinergic agents in rat brain

Hsi hsien Chou, Norio Ogawa, Masato Asanuma, Hiroshi Hirata, Yoichi Kondo, Akitane Mori

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M₁-receptor messenger RNA (M₁-R mRNA) in the rat striatum were studied. Carbachol increased the M₁-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.

Original language	English
Pages (from-to)	211-214
Number of pages	4
Journal	Molecular Brain Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0169-328X(93)90028-N
Publication status	Published - Aug 1993

Keywords

Carbachol
Muscarinic M receptor
Positive regulation
Rapid regulation
Rat striatum
Trihexyphenidyl
mRNA

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

Access to Document

10.1016/0169-328X(93)90028-N

Cite this

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title = "Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain",

abstract = "The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.",

keywords = "Carbachol, Muscarinic M receptor, Positive regulation, Rapid regulation, Rat striatum, Trihexyphenidyl, mRNA",

author = "Chou, {Hsi hsien} and Norio Ogawa and Masato Asanuma and Hiroshi Hirata and Yoichi Kondo and Akitane Mori",

note = "Funding Information: This study was supported in part by grants-in-aid for Scientific Research on Priority Areas and Scientific Research from the Japanese Ministry of Education, Science and Culture, and from the Japanese Ministry of Health and Welfare.",

year = "1993",

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T1 - Rapid response of striatal muscarinic M1-receptor mRNA to muscarinic cholinergic agents in rat brain

AU - Chou, Hsi hsien

AU - Ogawa, Norio

AU - Asanuma, Masato

AU - Hirata, Hiroshi

AU - Kondo, Yoichi

AU - Mori, Akitane

N1 - Funding Information: This study was supported in part by grants-in-aid for Scientific Research on Priority Areas and Scientific Research from the Japanese Ministry of Education, Science and Culture, and from the Japanese Ministry of Health and Welfare.

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N2 - The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.

AB - The effects of a single administration of muscarinic cholinergic agents on the level of muscarinic M1-receptor messenger RNA (M1-R mRNA) in the rat striatum were studied. Carbachol increased the M1-R mRNA expression rapidly and transiently, while trihexyphenidyl decreased it. These results suggest that muscarinic cholinergic agents participate in the positive regulation of muscarinic receptor mRNA in the early stage after treatment, contrary to the negative regulation in the chronic stage.

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KW - Muscarinic M receptor

KW - Positive regulation

KW - Rapid regulation

KW - Rat striatum

KW - Trihexyphenidyl

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