Reaction of spiro [piperidine-4,2′-(1′,2′,3′,4′-tetrahydroquinazolin)]-4′-ones with acetic anhydride

Masatoshi Yamato, Yasuo Takeuchi, Yuji Ikeda

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


The tetrahydro derivative (5a) and its aza derivative (5b) of antitumor active amsacrine were prepared. The key synthetic intermediate (3a) was simply prepared by rearrangement of spiro-compound (2a) by heating with acetic anhydride and pyridine. On the other hand, another key intermediate (3b) was obtained only during moderated reaction conditions, and the ring opening products (6b,b′ and 8b,b′) were obtained under the usal conditions.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
Issue number1
Publication statusPublished - Jan 1 1987

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry


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