Recent Advances in Transition-metal-catalyzed C−C Bond Formation via C(sp2)−F Bond Cleavage

Liyan Fu, Qiang Chen, Yasushi Nishihara

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

The activation of a carbon-fluorine bond is one of the most challenging topics in modern synthetic organic chemistry due to their low reactivity compared to other carbon-halogen bonds. In this review, we present the recent developments since 2015 on cross-coupling reactions that form C−C bonds via cleavage of C(sp2)−F bonds. Not only the conventional activation of C(sp2)−F bonds, but also decarbonylative or carbonyl-retentive cleavage of C(acyl)−F bonds will be introduced. This paper mainly describes new protocols for the formation of C(sp2)−C(sp3), C(sp2)−C(sp2), and C(sp2)−C(sp) bonds via transition-metal-catalyzed cleavage of C(sp2)−F bonds.

Original languageEnglish
Pages (from-to)3394-3410
Number of pages17
JournalChemical Record
Volume21
Issue number12
DOIs
Publication statusPublished - Dec 2021

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering
  • Materials Chemistry
  • Biochemistry

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