Recent topics of the stereodivergent synthesis of natural products

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11 Citations (Scopus)


A variety of natural products, a valuable source of drug lead compounds, coexist with their stereoisomers as congeners. For pursuing the structural elucidation and the structure–activity relationship study of natural products, it is needed to establish the streamlined synthetic route to supply natural products and their stereoisomers. Divergent pathway is one of the synthetic strategies to deliver more than one target compound. In this digest, selected examples of the stereodivergent approach toward the synthesis of natural products are described. Especially, this digest focuses on common synthetic intermediates and stereodiversification steps from the common intermediates to reach the target compounds.

Original languageEnglish
Pages (from-to)955-966
Number of pages12
JournalTetrahedron Letters
Issue number11
Publication statusPublished - Mar 14 2018


  • Natural product
  • Stereodivergent synthesis
  • Stereodiversification
  • Stereoisomer

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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