Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa

Koichiro Yamamoto; Daisuke Omura; Mai Yamane; Reina Son; Kou Hasegawa; Hiroyuki Honda; Mikako Obika; Nozomu Minao; Satoru Edahiro; Norihito Yamada; Fumio Otsuka

Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa

Koichiro Yamamoto, Daisuke Omura, Mai Yamane, Reina Son, Kou Hasegawa, Hiroyuki Honda, Mikako Obika, Nozomu Minao, Satoru Edahiro, Norihito Yamada, Fumio Otsuka

Research output: Contribution to journal › Article › peer-review

Abstract

Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m². Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypo-glycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

Original language	English
Pages (from-to)	631-636
Number of pages	6
Journal	Acta medica Okayama
Volume	75
Issue number	5
Publication status	Published - 2021

Keywords

anorexia nervosa
glucagon
hypoglycemic coma
insulin-like growth factor-I
liver injury

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa",

abstract = "Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypo-glycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.",

keywords = "anorexia nervosa, glucagon, hypoglycemic coma, insulin-like growth factor-I, liver injury",

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T1 - Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa

AU - Yamamoto, Koichiro

AU - Omura, Daisuke

AU - Yamane, Mai

AU - Son, Reina

AU - Hasegawa, Kou

AU - Honda, Hiroyuki

AU - Obika, Mikako

AU - Minao, Nozomu

AU - Edahiro, Satoru

AU - Yamada, Norihito

AU - Otsuka, Fumio

PY - 2021

Y1 - 2021

N2 - Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypo-glycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

AB - Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypo-glycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

KW - anorexia nervosa

KW - glucagon

KW - hypoglycemic coma

KW - insulin-like growth factor-I

KW - liver injury

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Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa

Abstract

Keywords

ASJC Scopus subject areas

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