Recurrence of Hypoglycemic Coma in a Patient with Anorexia Nervosa

Koichiro Yamamoto, Daisuke Omura, Mai Yamane, Reina Son, Kou Hasegawa, Hiroyuki Honda, Mikako Obika, Nozomu Minao, Satoru Edahiro, Norihito Yamada, Fumio Otsuka

Research output: Contribution to journalArticlepeer-review


Anorexia nervosa (AN) is occasionally complicated with hypoglycemic coma, which may cause sudden death by unknown mechanisms. We present the case of a 36-year-old woman with recurrent comas and a nineteen-year history of AN. She was found in a coma with remarkable hypoglycemia (28 mg/dL). Her BMI was 11.1 kg/m2. Endocrine workup revealed extremely low serum levels of glucagon, IGF-I and insulin. Asymptomatic hypo-glycemia occurred with liver injury in the refeeding process. An aberrant glucose metabolism due to liver damage might have been involved in her susceptibility to hypoglycemia. This case suggests a possible mechanism of hypoglycemic coma in AN.

Original languageEnglish
Pages (from-to)631-636
Number of pages6
JournalActa medica Okayama
Issue number5
Publication statusPublished - 2021


  • anorexia nervosa
  • glucagon
  • hypoglycemic coma
  • insulin-like growth factor-I
  • liver injury

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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