TY - JOUR
T1 - Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
AU - Takamizawa, Junichi
AU - Konishi, Hiroyuki
AU - Yanagisawa, Kiyoshi
AU - Tomida, Shuta
AU - Osada, Hirotaka
AU - Endoh, Hideki
AU - Harano, Tomoko
AU - Yatabe, Yasushi
AU - Nagino, Masato
AU - Nimura, Yuji
AU - Mitsudomi, Tetsuya
AU - Takahashi, Takashi
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2004/6/1
Y1 - 2004/6/1
N2 - In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.
AB - In this study, we report for the first time reduced expression of the let-7 microRNA in human lung cancers. Interestingly, 143 lung cancer cases that had undergone potentially curative resection could be classified into two major groups according to let-7 expression in unsupervised hierarchical analysis, showing significantly shorter survival after potentially curative resection in cases with reduced let-7 expression (P = 0.0003). Multivariate COX regression analysis showed this prognostic impact to be independent of disease stage (hazard ratio = 2.17; P = 0.009). In addition, overexpression of let-7 in A549 lung adenocarcinoma cell line inhibited lung cancer cell growth in vitro. This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration.
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U2 - 10.1158/0008-5472.CAN-04-0637
DO - 10.1158/0008-5472.CAN-04-0637
M3 - Article
C2 - 15172979
AN - SCOPUS:2542626605
SN - 0008-5472
VL - 64
SP - 3753
EP - 3756
JO - Cancer Research
JF - Cancer Research
IS - 11
ER -
