@article{359aff0ba4b840f389e48b05cc0b5fbe,
title = "Refraction-based 2D, 2.5D and 3D medical imaging: Stepping forward to a clinical trial",
abstract = "An attempt at refraction-based 2D, 2.5D and 3D X-ray imaging of articular cartilage and breast carcinoma is reported. We are developing very high contrast X-ray 2D imaging with XDFI (X-ray dark-field imaging), X-ray CT whose data are acquired by DEI (diffraction-enhanced imaging) and tomosynthesis due to refraction contrast. 2D and 2.5D images were taken with nuclear plates or with X-ray films. Microcalcification of breast cancer and articular cartilage are clearly visible. 3D data were taken with an X-ray sensitive CCD camera. The 3D image was successfully reconstructed by the use of an algorithm newly made by our group. This shows a distinctive internal structure of a ductus lactiferi (milk duct) that contains inner wall, intraductal carcinoma and multifocal calcification in the necrotic core of the continuous DCIS (ductal carcinoma in situ). Furthermore consideration of clinical applications of these contrasts made us to try tomosynthesis. This attempt was satisfactory from the view point of articular cartilage image quality and the skin radiation dose.",
keywords = "2.5D imaging, 2D imaging, 3D CT, DEI (diffraction-enhanced imaging), Ductal carcinoma in situ (DCIS), Microcalcification, Synchrotron radiation, Tomosynthesis, X-ray dark-field imaging (XDFI)",
author = "Masami Ando and Hiroko Bando and TokikoEndo and Shu Ichihara and Eiko Hashimoto and Kazuyuki Hyodo and Toshiyuki Kunisada and Gang Li and Anton Maksimenko and Kensaku Mori and Daisuke Shimao and Hiroshi Sugiyama and Tetsuya Yuasa and Ei Ueno",
note = "Funding Information: The authors would like to express their appreciation to Prof. Yamasaki Katsuhito who allows us to unlimited access to breast specimens. M. Ando was financially supported by a Grant-in-Aid for Exploratory Research (No. 15654042), a Grant-in-Aid for Scientific Research (A) (No. 18206011), a Grant-in-Aid for Youth Research (B) (No. 18791040) and a Grant-in-Aid for Youth Research B (No. 18790900) from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT), Suzuken Research Fund and the Horiba Special Award. Experiment was performed under the approval of the Programme Advisory Board at PF KEK with the project number of 2000G187, 2003G045, 2004PF07, 2004PF08, 2004PF09, 2004PF15, 004PF16, 2004PF23, 2004PF24, 2005G085, 2005PF02, 2005PF03, 2005PF08, 2005PF09, 2005PF13 and 2007G219. A necessary process of acquiring consent from the patient was done before experiment. Last but not the least the authors cannot disregard the great contribution of Prof. Takeda Yoshikazu at Nagoya University who proposed collaboration between the team of image processing at Nagoya University and the instrumentation group at KEK. As its product Fig. 4 came out.",
year = "2008",
month = dec,
doi = "10.1016/j.ejrad.2008.04.033",
language = "English",
volume = "68",
pages = "S32--S36",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "3 SUPPL.",
}
