Regenerative medicine for epilepsy: From basic research to clinical application

Takao Yasuhara; Takashi Agari; Masahiro Kameda; Akihiko Kondo; Satoshi Kuramoto; Meng Jing; Tatsuya Sasaki; Atsuhiko Toyoshima; Susumu Sasada; Kenichiro Sato; Aiko Shinko; Takaaki Wakamori; Yu Okuma; Yasuyuki Miyoshi; Naoki Tajiri; Cesario V. Borlongan; Isao Date

doi:10.3390/ijms141223390

Regenerative medicine for epilepsy: From basic research to clinical application

Takao Yasuhara, Takashi Agari, Masahiro Kameda, Akihiko Kondo, Satoshi Kuramoto, Meng Jing, Tatsuya Sasaki, Atsuhiko Toyoshima, Susumu Sasada, Kenichiro Sato, Aiko Shinko, Takaaki Wakamori, Yu Okuma, Yasuyuki Miyoshi, Naoki Tajiri, Cesario V. Borlongan, Isao Date

Research output: Contribution to journal › Review article › peer-review

8 Citations (Scopus)

Abstract

Epilepsy is a chronic neurological disorder, which presents with various forms of seizures. Traditional treatments, including medication using antiepileptic drugs, remain the treatment of choice for epilepsy. Recent development in surgical techniques and approaches has improved treatment outcomes. However, several epileptic patients still suffer from intractable seizures despite the advent of the multimodality of therapies. In this article, we initially provide an overview of clinical presentation of epilepsy then describe clinically relevant animal models of epilepsy. Subsequently, we discuss the concepts of regenerative medicine including cell therapy, neuroprotective agents, and electrical stimulation, which are reviewed within the context of our data.

Original language	English
Pages (from-to)	23390-23401
Number of pages	12
Journal	International journal of molecular sciences
Volume	14
Issue number	12
DOIs	https://doi.org/10.3390/ijms141223390
Publication status	Published - Nov 28 2013

Keywords

Brain-derived neurotrophic factor (BDNF)
Electrical stimulation
Erythropoietin
GABAergic neuron
Kainic acid
Kindling
Neural stem cell

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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Yasuhara, T., Agari, T., Kameda, M., Kondo, A., Kuramoto, S., Jing, M., Sasaki, T., Toyoshima, A., Sasada, S., Sato, K., Shinko, A., Wakamori, T., Okuma, Y., Miyoshi, Y., Tajiri, N., Borlongan, C. V., & Date, I. (2013). Regenerative medicine for epilepsy: From basic research to clinical application. International journal of molecular sciences, 14(12), 23390-23401. https://doi.org/10.3390/ijms141223390

Yasuhara, T, Agari, T, Kameda, M, Kondo, A, Kuramoto, S, Jing, M, Sasaki, T, Toyoshima, A, Sasada, S, Sato, K, Shinko, A, Wakamori, T, Okuma, Y, Miyoshi, Y, Tajiri, N, Borlongan, CV & Date, I 2013, 'Regenerative medicine for epilepsy: From basic research to clinical application', International journal of molecular sciences, vol. 14, no. 12, pp. 23390-23401. https://doi.org/10.3390/ijms141223390

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AU - Yasuhara, Takao

AU - Agari, Takashi

AU - Kameda, Masahiro

AU - Kondo, Akihiko

AU - Kuramoto, Satoshi

AU - Jing, Meng

AU - Sasaki, Tatsuya

AU - Toyoshima, Atsuhiko

AU - Sasada, Susumu

AU - Sato, Kenichiro

AU - Shinko, Aiko

AU - Wakamori, Takaaki

AU - Okuma, Yu

AU - Miyoshi, Yasuyuki

AU - Tajiri, Naoki

AU - Borlongan, Cesario V.

AU - Date, Isao

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KW - Brain-derived neurotrophic factor (BDNF)

KW - Electrical stimulation

KW - Erythropoietin

KW - GABAergic neuron

KW - Kainic acid

KW - Kindling

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Regenerative medicine for epilepsy: From basic research to clinical application

Abstract

Keywords

ASJC Scopus subject areas

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