TY - JOUR
T1 - Regional incidences of adult T-cell leukemia/lymphoma with cutaneous involvement in Japan
AU - Hamada, Toshihisa
AU - Nomura, Hayato
AU - Iwatsuki, Keiji
N1 - Funding Information:
ACKNOWLEDGMENTS: The authors would like to thank all our colleagues of the JDA who have kindly contributed to the present registration. This study was made possible by financial support from the Japanese Skin Cancer Society and grants from the Ministry of Health, Labor and Welfare, Japan (principal investigators, Drs Hirata and Uchimaru).
Funding Information:
The authors would like to thank all our colleagues of the JDA who have kindly contributed to the present registration. This study was made possible by financial support from the Japanese Skin Cancer Society and grants from the Ministry of Health, Labor and Welfare, Japan (principal investigators, Drs Hirata and Uchimaru). None declared
Publisher Copyright:
© 2017 Japanese Dermatological Association
PY - 2018/1
Y1 - 2018/1
N2 - Between 2008 and 2015, 462 newly-diagnosed adult T-cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). The 391 patients comprised 193 (50%) with smoldering type, 52 (13%) with chronic type, 44 (11%) with lymphoma type and 102 (26%) with acute type. The total number of patients in Kyushu/Okinawa was 8.8-times higher than that in Kanto, which was set as the reference value, while the estimated prevalence of human T-lymphotropic virus 1 (HTLV-1) carriers in Kyushu/Okinawa has been reported to be only 2.5-times higher than that in Kanto. In this study, the annual incidence of ATLL per 100 000 residents in Kyushu/Okinawa was 32-times higher than that in Kanto. Our results indicated the higher incidence rate of ATLL in the endemic area than those in the non-endemic areas in Japan, compared with the regional differences of HTLV-1 prevalence determined by serological HTLV-1 screening for blood donors. In addition, this analysis revealed that regional differences of mycosis fungoides/Sézary syndrome incidence rates were very small compared with those of ATLL.
AB - Between 2008 and 2015, 462 newly-diagnosed adult T-cell leukemia/lymphoma (ATLL) patients with cutaneous involvement were found from the nationwide registry for Japanese patients with cutaneous lymphoma, of which 391 were selected for the study. They ranged in age from 28 to 93 years (median, 69 years), and included 215 men and 176 women (male : female ratio = 1.2). The 391 patients comprised 193 (50%) with smoldering type, 52 (13%) with chronic type, 44 (11%) with lymphoma type and 102 (26%) with acute type. The total number of patients in Kyushu/Okinawa was 8.8-times higher than that in Kanto, which was set as the reference value, while the estimated prevalence of human T-lymphotropic virus 1 (HTLV-1) carriers in Kyushu/Okinawa has been reported to be only 2.5-times higher than that in Kanto. In this study, the annual incidence of ATLL per 100 000 residents in Kyushu/Okinawa was 32-times higher than that in Kanto. Our results indicated the higher incidence rate of ATLL in the endemic area than those in the non-endemic areas in Japan, compared with the regional differences of HTLV-1 prevalence determined by serological HTLV-1 screening for blood donors. In addition, this analysis revealed that regional differences of mycosis fungoides/Sézary syndrome incidence rates were very small compared with those of ATLL.
KW - adult T-cell leukemia/lymphoma
KW - human T-lymphotropic virus 1
KW - incidence
KW - mycosis fungoides
KW - transmission route
UR - http://www.scopus.com/inward/record.url?scp=85032208309&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032208309&partnerID=8YFLogxK
U2 - 10.1111/1346-8138.14100
DO - 10.1111/1346-8138.14100
M3 - Article
C2 - 29068084
AN - SCOPUS:85032208309
SN - 0385-2407
VL - 45
SP - 58
EP - 63
JO - Journal of Dermatology
JF - Journal of Dermatology
IS - 1
ER -