Regulation of endometrial prostaglandin F synthesis during luteolysis and early pregnancy in cattle

K. Okuda, Y. Miyamoto, D. J. Skarzynski

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89 Citations (Scopus)


Luteal regression is caused by a pulsatile release of prostaglandin (PG) F from the uterus in the late luteal phase in most mammals including cattle. Although it has been proposed in ruminants that pulsatile PGF secretion is generated by a positive feedback loop between luteal and/or hypophyseal oxytocin and uterine PGF, the bovine endometrium may possess other mechanisms for initiation of luteolytic PGF secretion. It has been recently demonstrated that tumor necrosis factor-α (TNF-α) stimulates PGF output from bovine endometrial tissue not only during the follicular phase but also during the late luteal phase, suggesting that TNF-α is a factor in the initiation of luteolysis in cattle. Furthermore, our recent study has shown that IFN-τ suppresses the action of TNF-α on PGF synthesis by the bovine endometrium in vitro, suggesting that IFN-τ plays a luteoprotective role by inhibiting TNF-α-induced PGF production in early pregnancy. On the other hand, factors other than oxytocin or TNF-α have also been suggested to be involved in the regulation of PGF synthesis by bovine endometrium. The purpose of this review is to summarize our current understanding of the endocrine mechanisms that regulate the timing and pattern of uterine PGF secretion during the estrous cycle and early pregnancy.

Original languageEnglish
Pages (from-to)255-264
Number of pages10
JournalDomestic Animal Endocrinology
Issue number1-2
Publication statusPublished - Jul 2002

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology
  • Endocrinology


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