Regulation of mammalian histamine synthesis: Histidine decarboxylase

Satoshi Tanaka, Atsushi Ichikawa

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Histamine plays a wide variety of physiological and pathological responses, such as immediate allergy, inflammation, gastric acid secretion, neurotransmission, and immune modulation. Histamine synthesis is mediated by the enzyme, L-histidine decarboxylase (HDC), which catalyzes decarboxylation of L-histidine. In contrast to extensive investigation and development of specific antagonists for histamine receptors, regulation of histamine synthesis remains to be clarified. We review here a series of studies about regulation of histamine synthesis, with a particular attention to the rate-limiting enzyme, HDC. We describe and discuss about the findings on various aspects of HDC, such as transcriptional regulation, post-translational regulation, and novel functions identified with the gene targeted mouse strain for HDC. It should be surely required for better understanding of the physiological roles of histamine to clarify the regulation of histamine synthesis, since accumulating evidence has indicated the critical roles of newly-formed histamine in health and disease.

Original languageEnglish
Title of host publicationBiomedical Aspects of Histamine
Subtitle of host publicationCurrent Perspectives
PublisherSpringer Netherlands
Number of pages16
ISBN (Print)9789048193486
Publication statusPublished - 2011


  • HDC
  • Histamine regulation
  • Histamine synthesis

ASJC Scopus subject areas

  • General Engineering


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