Reinfection rate following effective therapy against Helicobacter pylori infection in Japan

Masayasu Adachi, Motowo Mizuno, Kenji Yokota, Masatsugu Miyoshi, Yasuhiro Nagahara, Toshirou Maga, Kuniharu Ishiki, Tomoki Inaba, Hiroyuki Okada, Keiji Oguma, Takao Tsuji

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Background and Aim: In developed countries, reinfection of Helicobacter pylori (H. pylori) after eradication of the bacterium is unusual, while the reinfection rate in developing countries is variable. In this study, we determined the reinfection rate after successful H. pylori eradication in Japan, a country with a high prevalence of H. pylori infection. Methods: After successful eradication, 377 patients were followed up by endoscopy and urea breath test annually. In reinfected patients, H. pylori strains isolated initially and after reinfection were compared by using random amplification of polymorphic DNA fingerprinting. Results: H. pylori became positive in four of 337 patients (1.2%) 1 year after eradication and in two of 133 patients (1.5%) 2 years after eradication. One patient experienced an ulcer relapse 2 years after eradication therapy. Random amplification of polymorphic DNA fingerprinting of the isolated strains from four of the six patients showed two had identical strains (at 1 year) while the other two had different strains (one at 1 year and one at 2 years). When infection in the two patients reinfected with identical strains is considered a recrudescence, the true reinfection rate is<0.8% per patient year. Conclusions: The reinfection rate after eradication of H. pylori is low in Japan despite the country's high prevalence of H. pylori infection.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number1
Publication statusPublished - 2002
Externally publishedYes


  • Eradication therapy
  • Helicobacter pylori
  • Reinfection rate

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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