Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations

Ai Yamada; Hiroshi Moritake; Mariko Kinoshita; Daisuke Sawa; Sachiyo Kamimura; Shotaro Iwamoto; Yuka Yamashita; Jiro Inagaki; Takahide Takahashi; Akira Shimada; Megumi Obara; Hiroyuki Nunoi

doi:10.1111/ped.13010

Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations

Ai Yamada, Hiroshi Moritake, Mariko Kinoshita, Daisuke Sawa, Sachiyo Kamimura, Shotaro Iwamoto, Yuka Yamashita, Jiro Inagaki, Takahide Takahashi, Akira Shimada, Megumi Obara, Hiroyuki Nunoi

University Hospital

Research output: Contribution to journal › Comment/debate › peer-review

1 Citation (Scopus)

Abstract

Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.

Original language	English
Pages (from-to)	905-908
Number of pages	4
Journal	Pediatrics International
Volume	58
Issue number	9
DOIs	https://doi.org/10.1111/ped.13010
Publication status	Published - Sept 1 2016

Keywords

FLT3-internal tandem duplication
KIT
acute myeloid leukemia
allelic burden
inv(16)

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1111/ped.13010

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Yamada, A., Moritake, H., Kinoshita, M., Sawa, D., Kamimura, S., Iwamoto, S., Yamashita, Y., Inagaki, J., Takahashi, T., Shimada, A., Obara, M., & Nunoi, H. (2016). Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations. Pediatrics International, 58(9), 905-908. https://doi.org/10.1111/ped.13010

Yamada, A, Moritake, H, Kinoshita, M, Sawa, D, Kamimura, S, Iwamoto, S, Yamashita, Y, Inagaki, J, Takahashi, T, Shimada, A, Obara, M & Nunoi, H 2016, 'Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations', Pediatrics International, vol. 58, no. 9, pp. 905-908. https://doi.org/10.1111/ped.13010

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title = "Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations",

abstract = "Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.",

keywords = "FLT3-internal tandem duplication, KIT, acute myeloid leukemia, allelic burden, inv(16)",

author = "Ai Yamada and Hiroshi Moritake and Mariko Kinoshita and Daisuke Sawa and Sachiyo Kamimura and Shotaro Iwamoto and Yuka Yamashita and Jiro Inagaki and Takahide Takahashi and Akira Shimada and Megumi Obara and Hiroyuki Nunoi",

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doi = "10.1111/ped.13010",

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T1 - Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations

AU - Yamada, Ai

AU - Moritake, Hiroshi

AU - Kinoshita, Mariko

AU - Sawa, Daisuke

AU - Kamimura, Sachiyo

AU - Iwamoto, Shotaro

AU - Yamashita, Yuka

AU - Inagaki, Jiro

AU - Takahashi, Takahide

AU - Shimada, Akira

AU - Obara, Megumi

AU - Nunoi, Hiroyuki

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.

AB - Inversion of chromosome 16 [inv(16)] has a good prognosis in acute myeloid leukemia (AML), but additional genetic aberrations influence the outcome. We herein describe the case of a 15-year-old Japanese boy with inv(16) harboring a low-allelic burden internal tandem duplication of FLT3 (FLT3-ITD) and KIT mutations. Conventional chemotherapy eradicated a clone with a low-allelic burden FLT3-ITD mutation, although another clone with a KIT mutation occurred 17 months later. Further investigation is necessary to identify AML with inv(16) conferring poor prognosis, to facilitate appropriate treatment with additional drugs, such as dasatinib or gemtuzumab ozogamicin.

KW - FLT3-internal tandem duplication

KW - KIT

KW - acute myeloid leukemia

KW - allelic burden

KW - inv(16)

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DO - 10.1111/ped.13010

M3 - Comment/debate

C2 - 27460485

AN - SCOPUS:84979745100

SN - 1328-8067

VL - 58

SP - 905

EP - 908

JO - Pediatrics International

JF - Pediatrics International

IS - 9

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Relapsed childhood acute myeloid leukemia patient with inversion of chromosome 16 harboring a low FLT3 internal tandem duplication allelic burden and KIT mutations

Abstract

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